Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol
The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2012-11-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001100010&lng=en&tlng=en |
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| author | Reihaneh Sadeghian Masoud Fereidoni Mohammad Soukhtanloo Hamid Azizi-Malekabadi Mahmoud Hosseini |
| author_facet | Reihaneh Sadeghian Masoud Fereidoni Mohammad Soukhtanloo Hamid Azizi-Malekabadi Mahmoud Hosseini |
| author_sort | Reihaneh Sadeghian |
| collection | DOAJ |
| description | The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated. |
| format | Article |
| id | doaj-art-2c55e1a4a0a849ff8563eeed4240f069 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-11-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2c55e1a4a0a849ff8563eeed4240f0692025-08-20T02:01:43ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-11-01701187487910.1590/S0004-282X2012001100010S0004-282X2012001100010Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiolReihaneh Sadeghian0Masoud Fereidoni1Mohammad Soukhtanloo2Hamid Azizi-Malekabadi3Mahmoud Hosseini4Ferdowsi University of MashhadFerdowsi University of MashhadFerdowsi University of MashhadIslamic Azad UniversityMashhad University of Medical SciencesThe effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001100010&lng=en&tlng=enestradiolratohipocampoóxido nítrico |
| spellingShingle | Reihaneh Sadeghian Masoud Fereidoni Mohammad Soukhtanloo Hamid Azizi-Malekabadi Mahmoud Hosseini Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol Arquivos de Neuro-Psiquiatria estradiol rato hipocampo óxido nítrico |
| title | Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| title_full | Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| title_fullStr | Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| title_full_unstemmed | Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| title_short | Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| title_sort | decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol |
| topic | estradiol rato hipocampo óxido nítrico |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001100010&lng=en&tlng=en |
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