Challenges and Novelties in the Treatment of Obesity in Adults. A review
Introduction Obesity is a complex, chronic disease that continues to be a significant global health challenge due to its prevalence and association with numerous comorbidities. Etiology of this disease includes different factors from genetic, environmental, and lifestyle fields, while effective m...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2025-01-01
|
| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/57095 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559970958540800 |
|---|---|
| author | Karolina Kuczapska Marek Kurowski Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Paweł Moczydłowski Karolina Michalczuk |
| author_facet | Karolina Kuczapska Marek Kurowski Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Paweł Moczydłowski Karolina Michalczuk |
| author_sort | Karolina Kuczapska |
| collection | DOAJ |
| description |
Introduction
Obesity is a complex, chronic disease that continues to be a significant global health challenge due to its prevalence and association with numerous comorbidities. Etiology of this disease includes different factors from genetic, environmental, and lifestyle fields, while effective management of obesity is still being studied.
Aim of the study
The aim of this comprehensive review is to examine arising innovations in the treatment of adult obesity. Deeper insight into the available database would help to provide better understanding of obesity and of its treatment.
Materials and Methods
To reach satisfying results the research was conducted on the articles referring to obesity treatment from the Pubmed databases. Articles from recent years were preferably utilized to keep the review up to date.
Results
Nowadays, pharmacotherapy can offer GLP-1 receptor agonists like liraglutide or semaglutide, and new drugs like tirzepatide that show great effectiveness. Additionally, bariatric surgery continues to offer great solution for severe obesity, combining restrictive and malabsorptive mechanisms for significant weight loss and metabolic benefits. The main procedures include gastric bypass with sleeve gastrectomy or duodenal switch. Personalized treatment, referring to different obesity phenotypes, has shown improvement in the therapeutic outcomes. Some new therapies are studied including triple agonists (retatrutide), non-peptide GLP-1 receptor agonists, and drugs reaching other receptors. All of them are promising for the effective obesity treatment in the future.
Summary
This review underlines the need for multidisciplinary and personal approach in the treatment of obesity and the need to share the knowledge about it to address the growing obesity epidemic effectively. Recognizing obesity as a chronic and complex disease is essential to improve patient’s understanding of their condition as well as to reach effective treatment outcomes.
|
| format | Article |
| id | doaj-art-2c55070104cb4dff8d38bb782ae79957 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-2c55070104cb4dff8d38bb782ae799572025-01-05T08:16:31ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.57095Challenges and Novelties in the Treatment of Obesity in Adults. A reviewKarolina Kuczapska0https://orcid.org/0000-0002-5921-1094Marek Kurowski1https://orcid.org/0009-0008-2831-3312Anna Gliwa2https://orcid.org/0009-0006-0251-0591Monika Ryglewicz3https://orcid.org/0009-0006-1063-2265Dariusz Fabian4https://orcid.org/0009-0006-7241-7245Elżbieta Leszczyńska-Knaga5https://orcid.org/0009-0007-5584-8614Natalia Jakubczyk6https://orcid.org/0009-0008-3190-4658Weronika Rutkowska-Kawalec7https://orcid.org/0009-0002-4283-6458Paweł Moczydłowski8https://orcid.org/0009-0007-1555-2958Karolina Michalczuk9https://orcid.org/0000-0002-4427-9133University Clinical Hospital No. 4 in LublinIndependent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Łódź, Północna 42 street, 91-425 Łódź, PolandJan Mikulicz-Radecki University Clinical Hospital in Wrocław, Borowska 213 street, 50-556 Wrocław, Poland J.Popiełuszka Bielan Hospital, Independent Public Health Care Center, Cegłowska 80 street, 01-809 Warsaw, Poland Specialist Provincial Hospital in Ciechanów, Powstańców Wielkopolskich 2 street, 06-400 Ciechanów Megrez Provincial Specialist Hospital, Edukacja 102 street, 43-100 Tychy, Poland Independent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Łódź, Północna 42 street, 91-425 Łódź, Poland Dr. Tytus Chałubiński District Hospital in Zakopane, Kamieniec 10 street, 34-500 Zakopane, Poland G. Narutowicz Municipal Specialist Hospital, Prądnicka 35 street, 31-202 Kraków, Poland 5th Military Clinical Hospital with Polyclinic, Wrocławska 1/3 street, 30-901 Kraków, Poland Introduction Obesity is a complex, chronic disease that continues to be a significant global health challenge due to its prevalence and association with numerous comorbidities. Etiology of this disease includes different factors from genetic, environmental, and lifestyle fields, while effective management of obesity is still being studied. Aim of the study The aim of this comprehensive review is to examine arising innovations in the treatment of adult obesity. Deeper insight into the available database would help to provide better understanding of obesity and of its treatment. Materials and Methods To reach satisfying results the research was conducted on the articles referring to obesity treatment from the Pubmed databases. Articles from recent years were preferably utilized to keep the review up to date. Results Nowadays, pharmacotherapy can offer GLP-1 receptor agonists like liraglutide or semaglutide, and new drugs like tirzepatide that show great effectiveness. Additionally, bariatric surgery continues to offer great solution for severe obesity, combining restrictive and malabsorptive mechanisms for significant weight loss and metabolic benefits. The main procedures include gastric bypass with sleeve gastrectomy or duodenal switch. Personalized treatment, referring to different obesity phenotypes, has shown improvement in the therapeutic outcomes. Some new therapies are studied including triple agonists (retatrutide), non-peptide GLP-1 receptor agonists, and drugs reaching other receptors. All of them are promising for the effective obesity treatment in the future. Summary This review underlines the need for multidisciplinary and personal approach in the treatment of obesity and the need to share the knowledge about it to address the growing obesity epidemic effectively. Recognizing obesity as a chronic and complex disease is essential to improve patient’s understanding of their condition as well as to reach effective treatment outcomes. https://apcz.umk.pl/JEHS/article/view/57095obesitynutritionlifestylebariatric surgerypharmacotherapy in obesity |
| spellingShingle | Karolina Kuczapska Marek Kurowski Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Paweł Moczydłowski Karolina Michalczuk Challenges and Novelties in the Treatment of Obesity in Adults. A review Journal of Education, Health and Sport obesity nutrition lifestyle bariatric surgery pharmacotherapy in obesity |
| title | Challenges and Novelties in the Treatment of Obesity in Adults. A review |
| title_full | Challenges and Novelties in the Treatment of Obesity in Adults. A review |
| title_fullStr | Challenges and Novelties in the Treatment of Obesity in Adults. A review |
| title_full_unstemmed | Challenges and Novelties in the Treatment of Obesity in Adults. A review |
| title_short | Challenges and Novelties in the Treatment of Obesity in Adults. A review |
| title_sort | challenges and novelties in the treatment of obesity in adults a review |
| topic | obesity nutrition lifestyle bariatric surgery pharmacotherapy in obesity |
| url | https://apcz.umk.pl/JEHS/article/view/57095 |
| work_keys_str_mv | AT karolinakuczapska challengesandnoveltiesinthetreatmentofobesityinadultsareview AT marekkurowski challengesandnoveltiesinthetreatmentofobesityinadultsareview AT annagliwa challengesandnoveltiesinthetreatmentofobesityinadultsareview AT monikaryglewicz challengesandnoveltiesinthetreatmentofobesityinadultsareview AT dariuszfabian challengesandnoveltiesinthetreatmentofobesityinadultsareview AT elzbietaleszczynskaknaga challengesandnoveltiesinthetreatmentofobesityinadultsareview AT nataliajakubczyk challengesandnoveltiesinthetreatmentofobesityinadultsareview AT weronikarutkowskakawalec challengesandnoveltiesinthetreatmentofobesityinadultsareview AT pawełmoczydłowski challengesandnoveltiesinthetreatmentofobesityinadultsareview AT karolinamichalczuk challengesandnoveltiesinthetreatmentofobesityinadultsareview |