A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis
Tuberculosis is the leading cause of death worldwide from a single infectious agent; it has also been declared a threat to humanity by the World Health Organization. New insights indicate that the innate immune response plays a crucial role in determining the outcome of the infection. In this study,...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2025-02-01
|
| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2025019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849703955625410560 |
|---|---|
| author | Eduardo Ibargüen-Mondragón M. Victoria Otero-Espinar Miller Cerón Gómez |
| author_facet | Eduardo Ibargüen-Mondragón M. Victoria Otero-Espinar Miller Cerón Gómez |
| author_sort | Eduardo Ibargüen-Mondragón |
| collection | DOAJ |
| description | Tuberculosis is the leading cause of death worldwide from a single infectious agent; it has also been declared a threat to humanity by the World Health Organization. New insights indicate that the innate immune response plays a crucial role in determining the outcome of the infection. In this study, we assessed the role of macrophages in the innate immune response through a simple mathematical model. Our results confirm that macrophages provide the primary protective response against Mycobacterium tuberculosis. However, they also highlight the importance of other innate cells in the outcome of infection. Specifically, our findings suggest that, in addition to macrophage activity, the involvement of other innate immune cells is essential for eliminating or controlling bacterial progression, ultimately leading to an adaptive immune response. |
| format | Article |
| id | doaj-art-2c5002d409ac4b48aa43671edf5234b2 |
| institution | DOAJ |
| issn | 1551-0018 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-2c5002d409ac4b48aa43671edf5234b22025-08-20T03:16:58ZengAIMS PressMathematical Biosciences and Engineering1551-00182025-02-0122351152710.3934/mbe.2025019A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosisEduardo Ibargüen-Mondragón0M. Victoria Otero-Espinar1Miller Cerón Gómez2Departamento de Matemáticas y Estadística, Universidad de Nariño, Pasto 520002, ColombiaStatistics, Mathematical Analysis and Optimisation Department, Faculty of Mathematics, University of Santiago de Compostela (USC), and Galician Center for Mathematical Research and Technology (CITMAga), Santiago de Compostela 15782, SpainDepartamento de Matemáticas y Estadística, Universidad de Nariño, Pasto 520002, ColombiaTuberculosis is the leading cause of death worldwide from a single infectious agent; it has also been declared a threat to humanity by the World Health Organization. New insights indicate that the innate immune response plays a crucial role in determining the outcome of the infection. In this study, we assessed the role of macrophages in the innate immune response through a simple mathematical model. Our results confirm that macrophages provide the primary protective response against Mycobacterium tuberculosis. However, they also highlight the importance of other innate cells in the outcome of infection. Specifically, our findings suggest that, in addition to macrophage activity, the involvement of other innate immune cells is essential for eliminating or controlling bacterial progression, ultimately leading to an adaptive immune response.https://www.aimspress.com/article/doi/10.3934/mbe.2025019tuberculosisinnate immune responsewithin-host modelordinary differential equationqualitative analysisnormalized sensitivity index |
| spellingShingle | Eduardo Ibargüen-Mondragón M. Victoria Otero-Espinar Miller Cerón Gómez A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis Mathematical Biosciences and Engineering tuberculosis innate immune response within-host model ordinary differential equation qualitative analysis normalized sensitivity index |
| title | A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis |
| title_full | A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis |
| title_fullStr | A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis |
| title_full_unstemmed | A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis |
| title_short | A within-host model on the interaction dynamics between innate immune cells and Mycobacterium tuberculosis |
| title_sort | within host model on the interaction dynamics between innate immune cells and mycobacterium tuberculosis |
| topic | tuberculosis innate immune response within-host model ordinary differential equation qualitative analysis normalized sensitivity index |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2025019 |
| work_keys_str_mv | AT eduardoibarguenmondragon awithinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis AT mvictoriaoteroespinar awithinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis AT millercerongomez awithinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis AT eduardoibarguenmondragon withinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis AT mvictoriaoteroespinar withinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis AT millercerongomez withinhostmodelontheinteractiondynamicsbetweeninnateimmunecellsandmycobacteriumtuberculosis |