TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population
Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determin...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2013/473242 |
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| author | Xiao Yang Pengchao Li Xuejian Yang Chao Qin Qiang Cao Zhengdong Zhang Meilin Wang Hongzhou Cai Jinbao Gu Jun Tao Min Gu Qiang Lu Changjun Yin |
| author_facet | Xiao Yang Pengchao Li Xuejian Yang Chao Qin Qiang Cao Zhengdong Zhang Meilin Wang Hongzhou Cai Jinbao Gu Jun Tao Min Gu Qiang Lu Changjun Yin |
| author_sort | Xiao Yang |
| collection | DOAJ |
| description | Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results. No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (P=0.017). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions. In conclusion, TSP-1-1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population. |
| format | Article |
| id | doaj-art-2c4d83c15626478494323270866cf980 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-2c4d83c15626478494323270866cf9802025-02-03T06:42:19ZengWileyInternational Journal of Genomics2314-436X2314-43782013-01-01201310.1155/2013/473242473242TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese PopulationXiao Yang0Pengchao Li1Xuejian Yang2Chao Qin3Qiang Cao4Zhengdong Zhang5Meilin Wang6Hongzhou Cai7Jinbao Gu8Jun Tao9Min Gu10Qiang Lu11Changjun Yin12Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaCancer Center of Nanjing Medical University, Department of Molecular & Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, ChinaCancer Center of Nanjing Medical University, Department of Molecular & Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results. No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (P=0.017). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions. In conclusion, TSP-1-1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population.http://dx.doi.org/10.1155/2013/473242 |
| spellingShingle | Xiao Yang Pengchao Li Xuejian Yang Chao Qin Qiang Cao Zhengdong Zhang Meilin Wang Hongzhou Cai Jinbao Gu Jun Tao Min Gu Qiang Lu Changjun Yin TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population International Journal of Genomics |
| title | TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
| title_full | TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
| title_fullStr | TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
| title_full_unstemmed | TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
| title_short | TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
| title_sort | tsp 1 1223 a g polymorphism as a potential predictor of the recurrence risk of bladder cancer in a chinese population |
| url | http://dx.doi.org/10.1155/2013/473242 |
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