Maxillary angiosarcoma: a case report and literature review
Angiosarcoma is a rare and aggressive malignant mesenchymal neoplasia developing from endothelial cells, comprising only 2 % of soft tissues sarcomas. While primarily affecting soft tissues and skin, its occurrence in the oral cavity is exceptionally rare (1.6 %). We present the case of a 78-year-ol...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Oral and Maxillofacial Surgery Cases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214541925000185 |
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| author | Kamdem Benedikta Sala Nathalie Broome Martin May Laurence |
| author_facet | Kamdem Benedikta Sala Nathalie Broome Martin May Laurence |
| author_sort | Kamdem Benedikta |
| collection | DOAJ |
| description | Angiosarcoma is a rare and aggressive malignant mesenchymal neoplasia developing from endothelial cells, comprising only 2 % of soft tissues sarcomas. While primarily affecting soft tissues and skin, its occurrence in the oral cavity is exceptionally rare (1.6 %). We present the case of a 78-year-old woman with a nodular gingival lesion initially suspected as squamous cell carcinoma. Despite an uneventful postoperative course following maxillectomy, the histological examination revealed angiosarcoma. Discussion highlights the diagnostic challenges due to its varied clinical and histological presentation, often mimicking other lesions. Treatment involves complete surgical excision, followed by adjuvant chemotherapy and radiotherapy. However, the prognosis remains poor, with a high recurrence rate and metastatic potential. Our case underscores the importance of accurate diagnosis through comprehensive clinical, radiological, and histological evaluation, emphasizing the need for early detection and multidisciplinary management to improve outcomes in angiosarcoma patients. |
| format | Article |
| id | doaj-art-2c45391d90dd48258aebf2f9a027ecc3 |
| institution | DOAJ |
| issn | 2214-5419 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral and Maxillofacial Surgery Cases |
| spelling | doaj-art-2c45391d90dd48258aebf2f9a027ecc32025-08-20T03:05:53ZengElsevierOral and Maxillofacial Surgery Cases2214-54192025-06-0111210040310.1016/j.omsc.2025.100403Maxillary angiosarcoma: a case report and literature reviewKamdem Benedikta0Sala Nathalie1Broome Martin2May Laurence3Department of Maxillofacial Surgery, University Hospital Center of the Canton of Vaud (CHUV), Lausanne, Switzerland; Corresponding author. Service de chirurgie maxillo-faciale, Centre Hospitalier Universitaire Vaudois (CHUV), CH -1011, Lausanne, Switzerland.Department of Histopathology, University Hospital Center of the Canton of Vaud (CHUV), Lausanne, SwitzerlandDepartment of Maxillofacial Surgery, University Hospital Center of the Canton of Vaud (CHUV), Lausanne, SwitzerlandDepartment of Maxillofacial Surgery, University Hospital Center of the Canton of Vaud (CHUV), Lausanne, SwitzerlandAngiosarcoma is a rare and aggressive malignant mesenchymal neoplasia developing from endothelial cells, comprising only 2 % of soft tissues sarcomas. While primarily affecting soft tissues and skin, its occurrence in the oral cavity is exceptionally rare (1.6 %). We present the case of a 78-year-old woman with a nodular gingival lesion initially suspected as squamous cell carcinoma. Despite an uneventful postoperative course following maxillectomy, the histological examination revealed angiosarcoma. Discussion highlights the diagnostic challenges due to its varied clinical and histological presentation, often mimicking other lesions. Treatment involves complete surgical excision, followed by adjuvant chemotherapy and radiotherapy. However, the prognosis remains poor, with a high recurrence rate and metastatic potential. Our case underscores the importance of accurate diagnosis through comprehensive clinical, radiological, and histological evaluation, emphasizing the need for early detection and multidisciplinary management to improve outcomes in angiosarcoma patients.http://www.sciencedirect.com/science/article/pii/S2214541925000185 |
| spellingShingle | Kamdem Benedikta Sala Nathalie Broome Martin May Laurence Maxillary angiosarcoma: a case report and literature review Oral and Maxillofacial Surgery Cases |
| title | Maxillary angiosarcoma: a case report and literature review |
| title_full | Maxillary angiosarcoma: a case report and literature review |
| title_fullStr | Maxillary angiosarcoma: a case report and literature review |
| title_full_unstemmed | Maxillary angiosarcoma: a case report and literature review |
| title_short | Maxillary angiosarcoma: a case report and literature review |
| title_sort | maxillary angiosarcoma a case report and literature review |
| url | http://www.sciencedirect.com/science/article/pii/S2214541925000185 |
| work_keys_str_mv | AT kamdembenedikta maxillaryangiosarcomaacasereportandliteraturereview AT salanathalie maxillaryangiosarcomaacasereportandliteraturereview AT broomemartin maxillaryangiosarcomaacasereportandliteraturereview AT maylaurence maxillaryangiosarcomaacasereportandliteraturereview |