In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor

In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor

Abstract The Apelin receptor (APLNR), a class A G-protein coupled receptor, plays a crucial role during cardiovascular development and tumor angiogenesis. To understand its spatiotemporal activity in health and disease is fundamental for the development of drugs to manipulate its activation state. T...

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Bibliographic Details
Main Authors: Lukas Herdt, Hannes Schihada, Michael Kurz, Sebastian Ernst, Jean Eberlein, Peter Kolb, Cornelius Krasel, Moritz Bünemann, Christian S. M. Helker
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61781-3
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