Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study
Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2357746 |
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| author | Wenjie Dong Qiuyu Li Lei Chen Hui Tang Kun Tu Li Luo Longyang Jiang Yilan Huang |
| author_facet | Wenjie Dong Qiuyu Li Lei Chen Hui Tang Kun Tu Li Luo Longyang Jiang Yilan Huang |
| author_sort | Wenjie Dong |
| collection | DOAJ |
| description | Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of developing DN. A meta-analysis conducted by the MiBioGen consortium of the largest genome-wide association study (GWAS) provided aggregated data on the GM. DN data were obtained from the IEU database. The inverse-variance weighting (IVW) method was employed as the primary analytical approach. The IVW analysis indicated that genus Dialister (OR = 0.51, 95% CI: 0.34–0.77, p = 0.00118) was protective against DN. In addition, class Gammaproteobacteria (OR = 0.47, 95% CI: 0.27–0.83, p = 0.0096), class Lentisphaeria (OR =0.76, 95% CI: 0.68–0.99, p = 0.04), order Victivallales (OR = 0.76, 95% CI: 0.58–0.99, p = 0.04), and phylum Proteobacteria (OR = 0.53, 95% CI: 0.33–0.85, p = 0.00872) were negatively associated with the risk of developing DN. Genus LachnospiraceaeUCG008 (OR =1.45, 95% CI: 1.08–1.95, p = 0.01), order Bacteroidales (OR = 1.59, 95% CI: 1.02–2.49, p = 0.04), and genus Terrisporobacter (OR = 1.98, 95% CI: 1.14–3.45, p = 0.015) were positively associated with the risk of developing DN. In this study, we established a causal relationship between the genus Dialister and the risk of developing DN. Further trials are required to confirm the protective effects of probiotics on DN and to elucidate the precise protective mechanisms involving genus Dialister and DN. |
| format | Article |
| id | doaj-art-2c436f8a76f3479b9e85e49c63c149c0 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-2c436f8a76f3479b9e85e49c63c149c02025-08-20T03:05:25ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2357746Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization studyWenjie Dong0Qiuyu Li1Lei Chen2Hui Tang3Kun Tu4Li Luo5Longyang Jiang6Yilan Huang7Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, West China Second Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaNumerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of developing DN. A meta-analysis conducted by the MiBioGen consortium of the largest genome-wide association study (GWAS) provided aggregated data on the GM. DN data were obtained from the IEU database. The inverse-variance weighting (IVW) method was employed as the primary analytical approach. The IVW analysis indicated that genus Dialister (OR = 0.51, 95% CI: 0.34–0.77, p = 0.00118) was protective against DN. In addition, class Gammaproteobacteria (OR = 0.47, 95% CI: 0.27–0.83, p = 0.0096), class Lentisphaeria (OR =0.76, 95% CI: 0.68–0.99, p = 0.04), order Victivallales (OR = 0.76, 95% CI: 0.58–0.99, p = 0.04), and phylum Proteobacteria (OR = 0.53, 95% CI: 0.33–0.85, p = 0.00872) were negatively associated with the risk of developing DN. Genus LachnospiraceaeUCG008 (OR =1.45, 95% CI: 1.08–1.95, p = 0.01), order Bacteroidales (OR = 1.59, 95% CI: 1.02–2.49, p = 0.04), and genus Terrisporobacter (OR = 1.98, 95% CI: 1.14–3.45, p = 0.015) were positively associated with the risk of developing DN. In this study, we established a causal relationship between the genus Dialister and the risk of developing DN. Further trials are required to confirm the protective effects of probiotics on DN and to elucidate the precise protective mechanisms involving genus Dialister and DN.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2357746Diabetic nephropathygut microbiotacausal effectMendelian randomizationsingle nucleotide polymorphism |
| spellingShingle | Wenjie Dong Qiuyu Li Lei Chen Hui Tang Kun Tu Li Luo Longyang Jiang Yilan Huang Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study Renal Failure Diabetic nephropathy gut microbiota causal effect Mendelian randomization single nucleotide polymorphism |
| title | Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study |
| title_full | Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study |
| title_fullStr | Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study |
| title_full_unstemmed | Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study |
| title_short | Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study |
| title_sort | association between the gut microbiota and diabetic nephropathy a two sample mendelian randomization study |
| topic | Diabetic nephropathy gut microbiota causal effect Mendelian randomization single nucleotide polymorphism |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2357746 |
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