Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy
ObjectiveTo investigate the correlation of monocyte/high-density lipoprotein ratio （MHR） and urinary albumin/creatinine ratio （UACR） with the severity and prognosis of diabetic kidney disease （DKD）.MethodsA total of 115 DKD patients treated in Bengbu Second People's Hospital from May 1， 2021 to...
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Editorial Department of Journal of Clinical Nephrology
2025-03-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/article/doi/10.3969/j.issn.1671-2390.2025.03.003 |
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| author | Zhu Xiao-rui Lu Ming Guo Quan-quan |
| author_facet | Zhu Xiao-rui Lu Ming Guo Quan-quan |
| author_sort | Zhu Xiao-rui |
| collection | DOAJ |
| description | ObjectiveTo investigate the correlation of monocyte/high-density lipoprotein ratio （MHR） and urinary albumin/creatinine ratio （UACR） with the severity and prognosis of diabetic kidney disease （DKD）.MethodsA total of 115 DKD patients treated in Bengbu Second People's Hospital from May 1， 2021 to May 1， 2022 were prospectively enrolled. They were divided into stage 1 group， stage 2 group， stage 3 group and stage 4 group according to the degree of renal pathological injury. MHR and UACR of each group were compared， and Spearman correlation analysis was used to evaluate the correlation of MHR and UACR with DKD severity. After discharge， patients were followed up by outpatient visit or telephone contact for 1 year. According to whether they developed end-stage renal disease （ESRD）， the patients were divided into good prognosis group and poor prognosis group. Logistic multivariate regression analysis was used to identify the risk factors for the prognosis of DKD patients. The receiver operating characteristic curve （ROC） was plotted to evaluate the efficacy of MHR and UACR in predicting the poor prognosis of DKD.ResultsThere were significant differences in MHR and UACR among DKD patients with different stages （P<0.05）. The lowest MHR and UACR were detected in stage 1 group ［（5.35 ± 0.45） and （10.62 ± 2.15）， respectively］， and the highest values were found in stage 4 group ［（9.35 ± 1.02） and （200.50 ± 40.58）， respectively］. Spearman correlation analysis showed that MHR and UACR were positively correlated with the severity of DKD （r=0.867， 0.905， P<0.05）. There were significant differences in HBA1c ［（9.71 ± 1.08）% vs（ 12.95 ± 1.17）%］， total cholesterol ［（4.80 ± 0.85） mmol/L vs （8.56 ± 1.75） mmol/L］， triglyceride ［（1.46 ± 0.22） mmol/L vs （3.46 ± 0.52） mmol/L］， serum creatinine ［（89.12 ± 10.30） μmol/L vs （170.44 ± 22.85） μmol/L］， serum uric acid ［（5.18 ± 0.75） μmol/L vs （7.96 ± 1.16） μmol/L］， cystatin C ［（0.90 ± 0.15） mg/L vs （1.88 ± 0.42） mg/L］， low density lipoprotein ［（1.89 ± 0.46） mmol/L vs ［（3.85 ± 0.69） mmol/L］， MHR ［（4.38 ± 0.29） vs （11.05 ± 0.85）］ and UACR ［（21.69 ± 4.10） vs （170.16 ± 26.50）］ between good and bad prognosis groups （P<0.05）. Logistic multivariate regression analysis showed that hemoglobin A1c （OR=2.344， 95% CI： 1.925-2.764）， total cholesterol （OR=2.208， 95% CI： 1.940-2.476）， triglyceride （OR=2.234， 95% CI： 1.986-2.363）， serum creatinine （OR=2.328， 95% CI： 2.025-2.631）， serum uric acid （OR=2.351， 95% CI： 2.082-2.621）， cystatin C （OR=2.363， 95% CI： 2.071-2.655）， low density lipoprotein （OR=2.421， 95% CI： 2.165-2.676）， MHR （OR=2.489， 95% CI： 2.109-2.870）， UACR （OR=2.537， 95% CI： 2.106-2.968） were independent risk factors for poor prognosis of DKD. The above indicators were all correlated with the prognosis of DKD. ROC curve showed that the sensitivity and AUC of MHR combined with UACR in predicting the poor prognosis of DKD were 90.50% and 0.896， respectively， which were significantly higher than those of MHR （84.50%， 0.871） and UACR （82.50%， 0.853） alone.ConclusionMHR and UACR are correlated with DKD severity and patient prognosis， and the combination of MHR and UACR is more effective in predicting poor prognosis of DKD. |
| format | Article |
| id | doaj-art-2c43631fc2f1451d85ac7c8ca95f5009 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-2c43631fc2f1451d85ac7c8ca95f50092025-08-20T03:40:57ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902025-03-0125319420010.3969/j.issn.1671-2390.2025.03.0031671-2390（2025）03-0194-07Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathyZhu Xiao-rui0Lu Ming1Guo Quan-quan2Department of Endocrinology， Bengbu Municipal Second People's Hospital， Bengbu 233000， ChinaDepartment of Endocrinology， Bengbu Municipal Second People's Hospital， Bengbu 233000， ChinaDepartment of Endocrinology， Bengbu Municipal Second People's Hospital， Bengbu 233000， ChinaObjectiveTo investigate the correlation of monocyte/high-density lipoprotein ratio （MHR） and urinary albumin/creatinine ratio （UACR） with the severity and prognosis of diabetic kidney disease （DKD）.MethodsA total of 115 DKD patients treated in Bengbu Second People's Hospital from May 1， 2021 to May 1， 2022 were prospectively enrolled. They were divided into stage 1 group， stage 2 group， stage 3 group and stage 4 group according to the degree of renal pathological injury. MHR and UACR of each group were compared， and Spearman correlation analysis was used to evaluate the correlation of MHR and UACR with DKD severity. After discharge， patients were followed up by outpatient visit or telephone contact for 1 year. According to whether they developed end-stage renal disease （ESRD）， the patients were divided into good prognosis group and poor prognosis group. Logistic multivariate regression analysis was used to identify the risk factors for the prognosis of DKD patients. The receiver operating characteristic curve （ROC） was plotted to evaluate the efficacy of MHR and UACR in predicting the poor prognosis of DKD.ResultsThere were significant differences in MHR and UACR among DKD patients with different stages （P<0.05）. The lowest MHR and UACR were detected in stage 1 group ［（5.35 ± 0.45） and （10.62 ± 2.15）， respectively］， and the highest values were found in stage 4 group ［（9.35 ± 1.02） and （200.50 ± 40.58）， respectively］. Spearman correlation analysis showed that MHR and UACR were positively correlated with the severity of DKD （r=0.867， 0.905， P<0.05）. There were significant differences in HBA1c ［（9.71 ± 1.08）% vs（ 12.95 ± 1.17）%］， total cholesterol ［（4.80 ± 0.85） mmol/L vs （8.56 ± 1.75） mmol/L］， triglyceride ［（1.46 ± 0.22） mmol/L vs （3.46 ± 0.52） mmol/L］， serum creatinine ［（89.12 ± 10.30） μmol/L vs （170.44 ± 22.85） μmol/L］， serum uric acid ［（5.18 ± 0.75） μmol/L vs （7.96 ± 1.16） μmol/L］， cystatin C ［（0.90 ± 0.15） mg/L vs （1.88 ± 0.42） mg/L］， low density lipoprotein ［（1.89 ± 0.46） mmol/L vs ［（3.85 ± 0.69） mmol/L］， MHR ［（4.38 ± 0.29） vs （11.05 ± 0.85）］ and UACR ［（21.69 ± 4.10） vs （170.16 ± 26.50）］ between good and bad prognosis groups （P<0.05）. Logistic multivariate regression analysis showed that hemoglobin A1c （OR=2.344， 95% CI： 1.925-2.764）， total cholesterol （OR=2.208， 95% CI： 1.940-2.476）， triglyceride （OR=2.234， 95% CI： 1.986-2.363）， serum creatinine （OR=2.328， 95% CI： 2.025-2.631）， serum uric acid （OR=2.351， 95% CI： 2.082-2.621）， cystatin C （OR=2.363， 95% CI： 2.071-2.655）， low density lipoprotein （OR=2.421， 95% CI： 2.165-2.676）， MHR （OR=2.489， 95% CI： 2.109-2.870）， UACR （OR=2.537， 95% CI： 2.106-2.968） were independent risk factors for poor prognosis of DKD. The above indicators were all correlated with the prognosis of DKD. ROC curve showed that the sensitivity and AUC of MHR combined with UACR in predicting the poor prognosis of DKD were 90.50% and 0.896， respectively， which were significantly higher than those of MHR （84.50%， 0.871） and UACR （82.50%， 0.853） alone.ConclusionMHR and UACR are correlated with DKD severity and patient prognosis， and the combination of MHR and UACR is more effective in predicting poor prognosis of DKD.http://www.lcszb.com/article/doi/10.3969/j.issn.1671-2390.2025.03.003diabetic kidney diseasemonocytehigh density lipoproteinurinary albumin/creatinine ratioprognosis |
| spellingShingle | Zhu Xiao-rui Lu Ming Guo Quan-quan Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy Linchuang shenzangbing zazhi diabetic kidney disease monocyte high density lipoprotein urinary albumin/creatinine ratio prognosis |
| title | Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy |
| title_full | Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy |
| title_fullStr | Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy |
| title_full_unstemmed | Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy |
| title_short | Correlation of monocyte/high density lipoprotein and urinary albumin/creatinine ratio with the severity and prognosis of diabetic nephropathy |
| title_sort | correlation of monocyte high density lipoprotein and urinary albumin creatinine ratio with the severity and prognosis of diabetic nephropathy |
| topic | diabetic kidney disease monocyte high density lipoprotein urinary albumin/creatinine ratio prognosis |
| url | http://www.lcszb.com/article/doi/10.3969/j.issn.1671-2390.2025.03.003 |
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