Epigenetic Remodeling in Male Germline Development
In mammals, germ cells guarantee the inheritance of genetic and epigenetic information across generations and are the origin of a new organism. During embryo development, the blastocyst is formed in the early stage, is comprised of an inner cell mass which is pluripotent, and could give rise to the...
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/3152173 |
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| author | Na Li Qiaoyan Shen Jinlian Hua |
| author_facet | Na Li Qiaoyan Shen Jinlian Hua |
| author_sort | Na Li |
| collection | DOAJ |
| description | In mammals, germ cells guarantee the inheritance of genetic and epigenetic information across generations and are the origin of a new organism. During embryo development, the blastocyst is formed in the early stage, is comprised of an inner cell mass which is pluripotent, and could give rise to the embryonic stem cells (ESCs). The inner cell mass undergoes demethylation processes and will reestablish a methylated state that is similar to that of somatic cells later in epiblast stage. Primordial germ cells (PGCs) will be formed very soon and accompanied by the process of genome-wide demethylation. With the input of male sex determination genes, spermatogonial stem cells (SSCs) are generated and undergo the process of spermatogenesis. Spermatogenesis is a delicately regulated process in which various regulations are launched to guarantee normal mitosis and meiosis in SSCs. During all these processes, especially during spermatid development, DNA methylation profile and histone modifications are of crucial importance. In this review, we will discuss the epigenetic modifications from zygote formation to mature sperm generation and their significance to these development processes. |
| format | Article |
| id | doaj-art-2c42aca85aa94c1db3d4cd556f4d1610 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2c42aca85aa94c1db3d4cd556f4d16102025-08-20T03:55:17ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/31521733152173Epigenetic Remodeling in Male Germline DevelopmentNa Li0Qiaoyan Shen1Jinlian Hua2College of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering & Technology, Northwest A & F University, Yangling, Shaanxi, ChinaCollege of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering & Technology, Northwest A & F University, Yangling, Shaanxi, ChinaCollege of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering & Technology, Northwest A & F University, Yangling, Shaanxi, ChinaIn mammals, germ cells guarantee the inheritance of genetic and epigenetic information across generations and are the origin of a new organism. During embryo development, the blastocyst is formed in the early stage, is comprised of an inner cell mass which is pluripotent, and could give rise to the embryonic stem cells (ESCs). The inner cell mass undergoes demethylation processes and will reestablish a methylated state that is similar to that of somatic cells later in epiblast stage. Primordial germ cells (PGCs) will be formed very soon and accompanied by the process of genome-wide demethylation. With the input of male sex determination genes, spermatogonial stem cells (SSCs) are generated and undergo the process of spermatogenesis. Spermatogenesis is a delicately regulated process in which various regulations are launched to guarantee normal mitosis and meiosis in SSCs. During all these processes, especially during spermatid development, DNA methylation profile and histone modifications are of crucial importance. In this review, we will discuss the epigenetic modifications from zygote formation to mature sperm generation and their significance to these development processes.http://dx.doi.org/10.1155/2016/3152173 |
| spellingShingle | Na Li Qiaoyan Shen Jinlian Hua Epigenetic Remodeling in Male Germline Development Stem Cells International |
| title | Epigenetic Remodeling in Male Germline Development |
| title_full | Epigenetic Remodeling in Male Germline Development |
| title_fullStr | Epigenetic Remodeling in Male Germline Development |
| title_full_unstemmed | Epigenetic Remodeling in Male Germline Development |
| title_short | Epigenetic Remodeling in Male Germline Development |
| title_sort | epigenetic remodeling in male germline development |
| url | http://dx.doi.org/10.1155/2016/3152173 |
| work_keys_str_mv | AT nali epigeneticremodelinginmalegermlinedevelopment AT qiaoyanshen epigeneticremodelinginmalegermlinedevelopment AT jinlianhua epigeneticremodelinginmalegermlinedevelopment |