Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis
PurposeThis study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.MethodsA systematic search was conducted using PubMed, Embase, and Cochrane Library from the ince...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519999/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556627469107200 |
|---|---|
| author | Jin Li Yu-Bo Liang Qing-Bo Wang Yu-Kai Li Xing-Ming Chen Wan-Ling Luo Yawhan Lakang Zi-Sheng Yang Yan Wang Zhi-Wei Li Yang Ke Yang Ke Yang Ke |
| author_facet | Jin Li Yu-Bo Liang Qing-Bo Wang Yu-Kai Li Xing-Ming Chen Wan-Ling Luo Yawhan Lakang Zi-Sheng Yang Yan Wang Zhi-Wei Li Yang Ke Yang Ke Yang Ke |
| author_sort | Jin Li |
| collection | DOAJ |
| description | PurposeThis study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.MethodsA systematic search was conducted using PubMed, Embase, and Cochrane Library from the inception to July 31, 2024 for literature that reported the role of LVD in overall survival (OS) and recurrence-free survival (RFS) of patients with HBP cancers after radical resection.ResultsTen studies with 761 patients were included for the meta-analysis. The results indicated that a higher level of LVD was associated with worse OS (hazard ratio, HR = 2.87, 95% CI 1.63 to 5.04) and worse RFS (HR = 3.18, 95% CI 1.41 to 7.17) in HBP cancers. Subgroup analysis based on pathological types revealed that a higher level of LVD was significantly related to worse OS in hepatocellular carcinoma (HCC) (HR = 2.35, 95% CI 1.16 to 4.78), cholangiocarcinoma (HR = 4.65, 95% CI 1.70 to 12.70), and gallbladder cancer patients (HR = 4.64, 95% CI 1.37 to 15.71). The levels of LVD were not significantly associated with OS in pancreatic adenocarcinoma patients after radical resection (HR = 1.08, 95% CI 0.61 to 1.89). Similarly, a higher level of LVD was significantly associated with worse RFS in HCC (HR = 1.92, 95% CI 1.01 to 3.65) and cholangiocarcinoma patients (HR = 4.54, 95% CI 2.10 to 9.83).ConclusionsA higher level of LVD was a biomarker for the prediction of worse OS and RFS in patients with hepatobiliary cancers after radical resection.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024571167. |
| format | Article |
| id | doaj-art-2c40adc6c6674e68884a3fd19edfd232 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-2c40adc6c6674e68884a3fd19edfd2322025-01-07T06:51:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15199991519999Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysisJin Li0Yu-Bo Liang1Qing-Bo Wang2Yu-Kai Li3Xing-Ming Chen4Wan-Ling Luo5Yawhan Lakang6Zi-Sheng Yang7Yan Wang8Zhi-Wei Li9Yang Ke10Yang Ke11Yang Ke12Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Pathology, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Surgical Education and Research, The Second Affiliated Hospital, Kunming Medical University, Kunming, ChinaYunnan Yunke Bio-Technology Institution, Kunming, ChinaPurposeThis study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.MethodsA systematic search was conducted using PubMed, Embase, and Cochrane Library from the inception to July 31, 2024 for literature that reported the role of LVD in overall survival (OS) and recurrence-free survival (RFS) of patients with HBP cancers after radical resection.ResultsTen studies with 761 patients were included for the meta-analysis. The results indicated that a higher level of LVD was associated with worse OS (hazard ratio, HR = 2.87, 95% CI 1.63 to 5.04) and worse RFS (HR = 3.18, 95% CI 1.41 to 7.17) in HBP cancers. Subgroup analysis based on pathological types revealed that a higher level of LVD was significantly related to worse OS in hepatocellular carcinoma (HCC) (HR = 2.35, 95% CI 1.16 to 4.78), cholangiocarcinoma (HR = 4.65, 95% CI 1.70 to 12.70), and gallbladder cancer patients (HR = 4.64, 95% CI 1.37 to 15.71). The levels of LVD were not significantly associated with OS in pancreatic adenocarcinoma patients after radical resection (HR = 1.08, 95% CI 0.61 to 1.89). Similarly, a higher level of LVD was significantly associated with worse RFS in HCC (HR = 1.92, 95% CI 1.01 to 3.65) and cholangiocarcinoma patients (HR = 4.54, 95% CI 2.10 to 9.83).ConclusionsA higher level of LVD was a biomarker for the prediction of worse OS and RFS in patients with hepatobiliary cancers after radical resection.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024571167.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519999/fullbile duct cancerhepatocellular carcinomaliver cancerlymphangiogenesispancreatic cancerprognosis |
| spellingShingle | Jin Li Yu-Bo Liang Qing-Bo Wang Yu-Kai Li Xing-Ming Chen Wan-Ling Luo Yawhan Lakang Zi-Sheng Yang Yan Wang Zhi-Wei Li Yang Ke Yang Ke Yang Ke Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis Frontiers in Immunology bile duct cancer hepatocellular carcinoma liver cancer lymphangiogenesis pancreatic cancer prognosis |
| title | Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis |
| title_full | Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis |
| title_fullStr | Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis |
| title_full_unstemmed | Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis |
| title_short | Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis |
| title_sort | tumor associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers a systematic review and meta analysis |
| topic | bile duct cancer hepatocellular carcinoma liver cancer lymphangiogenesis pancreatic cancer prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519999/full |
| work_keys_str_mv | AT jinli tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yuboliang tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT qingbowang tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yukaili tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT xingmingchen tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT wanlingluo tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yawhanlakang tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT zishengyang tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yanwang tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT zhiweili tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yangke tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yangke tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis AT yangke tumorassociatedlymphaticvesseldensityisapostoperativeprognosticbiomarkerofhepatobiliarycancersasystematicreviewandmetaanalysis |