Synthese bei Temperaturen unter −80°C
Small differences in free enthalpies of activation (ΔΔG‡) between competing reactions give rise to high selectivity at low enough temperatures. Special techniques are necessary, in order to exploit this effect in preparative-scale conversions. An experimental set-up is described here with which rea...
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| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1983-12-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9600 |
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| _version_ | 1850140269506199552 |
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| author | Dieter Seebach August Hidber |
| author_facet | Dieter Seebach August Hidber |
| author_sort | Dieter Seebach |
| collection | DOAJ |
| description |
Small differences in free enthalpies of activation (ΔΔG‡) between competing reactions give rise to high selectivity at low enough temperatures. Special techniques are necessary, in order to exploit this effect in preparative-scale conversions. An experimental set-up is described here with which reactions can conveniently be carried out in up to five liter flasks at temperatures down to -150°C. In one apparatus, the cooling bath is liquid, in another one the reaction vessel is cooled directly by evaporating liquid nitrogen. Applications described are brominations of C,C double bonds and reactions of lithium enolates with electrophiles.
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| format | Article |
| id | doaj-art-2c3db31068ee4fa1be4efd26e4d645a9 |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1983-12-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-2c3db31068ee4fa1be4efd26e4d645a92025-08-20T02:29:52ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241983-12-01371210.2533/chimia.1983.449Synthese bei Temperaturen unter −80°CDieter Seebach0August Hidber1Laboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 ZürichLaboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich Small differences in free enthalpies of activation (ΔΔG‡) between competing reactions give rise to high selectivity at low enough temperatures. Special techniques are necessary, in order to exploit this effect in preparative-scale conversions. An experimental set-up is described here with which reactions can conveniently be carried out in up to five liter flasks at temperatures down to -150°C. In one apparatus, the cooling bath is liquid, in another one the reaction vessel is cooled directly by evaporating liquid nitrogen. Applications described are brominations of C,C double bonds and reactions of lithium enolates with electrophiles. https://www.chimia.ch/chimia/article/view/9600 |
| spellingShingle | Dieter Seebach August Hidber Synthese bei Temperaturen unter −80°C CHIMIA |
| title | Synthese bei Temperaturen unter −80°C |
| title_full | Synthese bei Temperaturen unter −80°C |
| title_fullStr | Synthese bei Temperaturen unter −80°C |
| title_full_unstemmed | Synthese bei Temperaturen unter −80°C |
| title_short | Synthese bei Temperaturen unter −80°C |
| title_sort | synthese bei temperaturen unter 80°c |
| url | https://www.chimia.ch/chimia/article/view/9600 |
| work_keys_str_mv | AT dieterseebach synthesebeitemperaturenunter80c AT augusthidber synthesebeitemperaturenunter80c |