Therapeutic mechanistic study of novel indole derivatives as SIRTUIN3 modulators in Parkinson’s disease with in vitro evaluation

Therapeutic mechanistic study of novel indole derivatives as SIRTUIN3 modulators in Parkinson’s disease with in vitro evaluation

Abstract SIRT3 modulates reactive oxygen species and helps to reduce oxidative stress, resulting in a neuroprotective effect in Parkinson’s disease. The work seeks to develop and synthesize novel, effective SIRT3 modulators, which will modify SIRT3 expression and generate the neuroprotective effect...

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Bibliographic Details
Main Authors: Jagdish Chand, Srikanth Jupudi, Sheikh F. Ahmad, Talha Bin Emran, Gomathy Subramanian
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Molecular docking
Indole derivatives
Parkinson’s disease
SIRT3
SHSY-5Y neuroblastoma cell lines
Online Access:https://doi.org/10.1038/s41598-025-99534-3
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