MUSHROOMS4LIFE: Decoding the Molecular Basis of a Cancer-Fighting Small RNA Extracted from Edible Mushrooms
Edible mushrooms have been considered an excellent source of nutraceuticals with high potential to prevent diseases such as cancer. Recently the anti-cancer potential of a small RNA (sRNA) fraction isolated from <i>C. cibarius</i> was described. To better understand its molecular nature,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
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| Series: | Medical Sciences Forum |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9992/23/1/9 |
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| Summary: | Edible mushrooms have been considered an excellent source of nutraceuticals with high potential to prevent diseases such as cancer. Recently the anti-cancer potential of a small RNA (sRNA) fraction isolated from <i>C. cibarius</i> was described. To better understand its molecular nature, a study was carried out regarding the anti-cancer potential of sRNAs isolated from different mushroom species. Apart from the isolation of RNA-rich fractions by anion exchange chromatography, miRNA’s extraction was also carried out using a commercial kit. The anti-proliferative activity of the different samples was tested in normal and cancer cell lines. Our data demonstrated differences regarding sRNA anti-cancer activity in different mushroom species, and this suggests that the sRNA fractions with anti-cancer potential are enriched in a specific sequence. These results reaffirm mushrooms as a source of bioactive compounds. In particular, the RNA-enriched isolated fractions demonstrated important anticancer potential. |
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| ISSN: | 2673-9992 |