Chymotrypsin-like and caspase-like proteasome activities in breast cancer
The chymotrypsin-like and caspase-like proteasome activities were studied in tumor tissues of 74 patients with breast cancer (BC) NМin association with tumor size and lymph node involvement. Chymotrypsin-like and caspase-like proteasome activities were Т1-40-30 higher in breast cancer tissue than in...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408285163126784 |
|---|---|
| author | E. E. Shashova I. V. Kondakova E. M. Slonimskaya S. A. Glushenko E. S. Kolegova |
| author_facet | E. E. Shashova I. V. Kondakova E. M. Slonimskaya S. A. Glushenko E. S. Kolegova |
| author_sort | E. E. Shashova |
| collection | DOAJ |
| description | The chymotrypsin-like and caspase-like proteasome activities were studied in tumor tissues of 74 patients with breast cancer (BC) NМin association with tumor size and lymph node involvement. Chymotrypsin-like and caspase-like proteasome activities were Т1-40-30 higher in breast cancer tissue than in adjacent tissues. We showed that advanced BC is accompanied by increase in chymotrypsin-like and caspase-like proteasome activities. In tumors with lymph node dissemination, proteasome activity was significantly decreased, which may have prospective prognostic value. Taken together, our data indicate an important role of intracellular proteolysis in BC progression. |
| format | Article |
| id | doaj-art-2c33ce281ef14fde8117db8fad06695b |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-2c33ce281ef14fde8117db8fad06695b2025-08-20T03:35:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01054549238Chymotrypsin-like and caspase-like proteasome activities in breast cancerE. E. Shashova0I. V. Kondakova1E. M. Slonimskaya2S. A. Glushenko3E. S. Kolegova4Cancer Research Institute, SB RAMS, TomskCancer Research Institute, SB RAMS, TomskCancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, TomskCancer Research Institute, SB RAMS, TomskSiberian State Medical University, TomskThe chymotrypsin-like and caspase-like proteasome activities were studied in tumor tissues of 74 patients with breast cancer (BC) NМin association with tumor size and lymph node involvement. Chymotrypsin-like and caspase-like proteasome activities were Т1-40-30 higher in breast cancer tissue than in adjacent tissues. We showed that advanced BC is accompanied by increase in chymotrypsin-like and caspase-like proteasome activities. In tumors with lymph node dissemination, proteasome activity was significantly decreased, which may have prospective prognostic value. Taken together, our data indicate an important role of intracellular proteolysis in BC progression.https://www.siboncoj.ru/jour/article/view/238breast cancerproteasome activitylymph node metastasis |
| spellingShingle | E. E. Shashova I. V. Kondakova E. M. Slonimskaya S. A. Glushenko E. S. Kolegova Chymotrypsin-like and caspase-like proteasome activities in breast cancer Сибирский онкологический журнал breast cancer proteasome activity lymph node metastasis |
| title | Chymotrypsin-like and caspase-like proteasome activities in breast cancer |
| title_full | Chymotrypsin-like and caspase-like proteasome activities in breast cancer |
| title_fullStr | Chymotrypsin-like and caspase-like proteasome activities in breast cancer |
| title_full_unstemmed | Chymotrypsin-like and caspase-like proteasome activities in breast cancer |
| title_short | Chymotrypsin-like and caspase-like proteasome activities in breast cancer |
| title_sort | chymotrypsin like and caspase like proteasome activities in breast cancer |
| topic | breast cancer proteasome activity lymph node metastasis |
| url | https://www.siboncoj.ru/jour/article/view/238 |
| work_keys_str_mv | AT eeshashova chymotrypsinlikeandcaspaselikeproteasomeactivitiesinbreastcancer AT ivkondakova chymotrypsinlikeandcaspaselikeproteasomeactivitiesinbreastcancer AT emslonimskaya chymotrypsinlikeandcaspaselikeproteasomeactivitiesinbreastcancer AT saglushenko chymotrypsinlikeandcaspaselikeproteasomeactivitiesinbreastcancer AT eskolegova chymotrypsinlikeandcaspaselikeproteasomeactivitiesinbreastcancer |