Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling

Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling

In the textbook view, NMDA receptors (NMDARs) act as coincidence detectors in Hebbian plasticity by fluxing Ca2+ when simultaneously depolarized and glutamate bound. Hebbian coincidence detection requires that NMDARs be located postsynaptically, but enigmatic presynaptic NMDARs (preNMDARs) also exis...

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Bibliographic Details
Main Authors: Aurore Thomazeau, Sabine Rannio, Jennifer A Brock, Hovy Ho-Wai Wong, Per Jesper Sjöström
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
long-term plasticity
STDP
LTD
LTP
NMDA receptor
Online Access:https://elifesciences.org/articles/106284
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