Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications
Abstract Background Helicobacter pylori (H. pylori) is known to induce chronic inflammatory conditions, and interactions between the host immune system and pathogen have diverted attention toward investigating its correlation with extra-gastrointestinal disorders. Objective The present study aimed t...
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2025-03-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
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| Online Access: | https://doi.org/10.1186/s12941-025-00788-6 |
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| author | Somayeh Yaslianifard Fatemeh Sameni Kimia Kazemi Yousef Atefpour Bahareh Hajikhani Ali Baradaran Bagheri Shahrooz Yazdani Masoud Dadashi |
| author_facet | Somayeh Yaslianifard Fatemeh Sameni Kimia Kazemi Yousef Atefpour Bahareh Hajikhani Ali Baradaran Bagheri Shahrooz Yazdani Masoud Dadashi |
| author_sort | Somayeh Yaslianifard |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori (H. pylori) is known to induce chronic inflammatory conditions, and interactions between the host immune system and pathogen have diverted attention toward investigating its correlation with extra-gastrointestinal disorders. Objective The present study aimed to assess the rate of H. pylori infection in cardiovascular disease (CVD) through a systematic review and meta-analysis. Methods We conducted a large-scale meta-analysis to determine the prevalence rates of H. pylori infection in vascular diseases. Articles from PubMed/Medline, Web of Science, and Embase databases published between 2000 and 2023 were included for analysis. We used multiple independent observers to extract data, calculated the pooled frequency of H. pylori in vascular diseases using a random effect model, and reported the results as a weighted average based on the study population. The main outcome measures were presented with 95% confidence intervals (CI). Results In 87 included studies, the prevalence of H. pylori infection in vascular diseases was 56.7% worldwide. 14.25% of H. pylori isolates harbored the cagA gene. The predominant vascular complication was coronary artery disease (CAD) (31.07%), primarily documented in Europe. This meta-analysis revealed a declining emphasis on studying the association of H. pylori infection with vascular disease in recent times. Conclusion According to this meta-analysis, H. pylori infection has a high frequency in CVD and may increase the risk of vascular diseases. However, further research is required, particularly in nations with limited data. |
| format | Article |
| id | doaj-art-2c2ae2ff124c4122aa2568f3ab7c2615 |
| institution | DOAJ |
| issn | 1476-0711 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj-art-2c2ae2ff124c4122aa2568f3ab7c26152025-08-20T02:51:23ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112025-03-0124111610.1186/s12941-025-00788-6Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complicationsSomayeh Yaslianifard0Fatemeh Sameni1Kimia Kazemi2Yousef Atefpour3Bahareh Hajikhani4Ali Baradaran Bagheri5Shahrooz Yazdani6Masoud Dadashi7Department of Microbiology, School of Medicine, Alborz University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Shahed UniversityDepartment of Microbiology, School of Medicine, Alborz University of Medical SciencesDepartment of Microbiology, School of Medicine, Alborz University of Medical SciencesDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Neurosurgery, Shahid Madani Hospital, Alborz University of Medical SciencesDepartment of Cardiology, School of Medicine, Alborz University of Medical SciencesDepartment of Microbiology, School of Medicine, Alborz University of Medical SciencesAbstract Background Helicobacter pylori (H. pylori) is known to induce chronic inflammatory conditions, and interactions between the host immune system and pathogen have diverted attention toward investigating its correlation with extra-gastrointestinal disorders. Objective The present study aimed to assess the rate of H. pylori infection in cardiovascular disease (CVD) through a systematic review and meta-analysis. Methods We conducted a large-scale meta-analysis to determine the prevalence rates of H. pylori infection in vascular diseases. Articles from PubMed/Medline, Web of Science, and Embase databases published between 2000 and 2023 were included for analysis. We used multiple independent observers to extract data, calculated the pooled frequency of H. pylori in vascular diseases using a random effect model, and reported the results as a weighted average based on the study population. The main outcome measures were presented with 95% confidence intervals (CI). Results In 87 included studies, the prevalence of H. pylori infection in vascular diseases was 56.7% worldwide. 14.25% of H. pylori isolates harbored the cagA gene. The predominant vascular complication was coronary artery disease (CAD) (31.07%), primarily documented in Europe. This meta-analysis revealed a declining emphasis on studying the association of H. pylori infection with vascular disease in recent times. Conclusion According to this meta-analysis, H. pylori infection has a high frequency in CVD and may increase the risk of vascular diseases. However, further research is required, particularly in nations with limited data.https://doi.org/10.1186/s12941-025-00788-6Helicobacter pyloriCardiovascular diseaseCoronary artery diseasecagA |
| spellingShingle | Somayeh Yaslianifard Fatemeh Sameni Kimia Kazemi Yousef Atefpour Bahareh Hajikhani Ali Baradaran Bagheri Shahrooz Yazdani Masoud Dadashi Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications Annals of Clinical Microbiology and Antimicrobials Helicobacter pylori Cardiovascular disease Coronary artery disease cagA |
| title | Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications |
| title_full | Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications |
| title_fullStr | Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications |
| title_full_unstemmed | Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications |
| title_short | Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications |
| title_sort | beyond the gut a comprehensive meta analysis on helicobacter pylori infection and cardiovascular complications |
| topic | Helicobacter pylori Cardiovascular disease Coronary artery disease cagA |
| url | https://doi.org/10.1186/s12941-025-00788-6 |
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