Comorbidities’ Effect on IPF: Pathogenesis and Management
In recent years, there has been a growing recognition within the medical community that idiopathic pulmonary fibrosis (IPF) cannot be effectively managed through a singular focus on the disease itself. Instead, a dual approach is essential, one that not only aims to prolong survival by targeting the...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/6/1362 |
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| author | Andrea Salotti Maria Chianese Antonio Romallo Anna De Nes Darina Angoni Alessandra Galantino Maria Chernovsky Lucrezia Mondini Francesco Salton Paola Confalonieri Rossella Cifaldi Pietro Geri Micol Pividori Giulia Bandini Michael Hughes Marco Confalonieri Marta Maggisano Barbara Ruaro |
| author_facet | Andrea Salotti Maria Chianese Antonio Romallo Anna De Nes Darina Angoni Alessandra Galantino Maria Chernovsky Lucrezia Mondini Francesco Salton Paola Confalonieri Rossella Cifaldi Pietro Geri Micol Pividori Giulia Bandini Michael Hughes Marco Confalonieri Marta Maggisano Barbara Ruaro |
| author_sort | Andrea Salotti |
| collection | DOAJ |
| description | In recent years, there has been a growing recognition within the medical community that idiopathic pulmonary fibrosis (IPF) cannot be effectively managed through a singular focus on the disease itself. Instead, a dual approach is essential, one that not only aims to prolong survival by targeting the underlying pathological mechanisms of IPF but also addresses the numerous comorbidities that frequently complicate the clinical picture for affected individuals. This narrative review seeks to provide a detailed and comprehensive exploration of the various comorbid conditions associated with IPF, which may include cardiovascular disease (CVD), lung cancer (LC), gastroesophageal reflux disease (GERD), obstructive sleep apnea (OSA), and anxiety/depression, among others. By understanding the interplay between these comorbidities and IPF, healthcare providers can better tailor treatment regimens to meet the holistic needs of patients. Furthermore, this review delves into both current management strategies and emerging therapeutic approaches for these comorbidities, emphasizing the importance of interdisciplinary collaboration in clinical practice. By synthesizing the latest research and clinical insights, this review aims to enhance awareness and understanding of the complexities surrounding IPF management, ultimately guiding clinicians in developing more effective, individualized care plans that address not only the fibrotic lung disease but also the broader spectrum of health challenges faced by patients. Through this comprehensive overview, we hope to contribute to the ongoing dialogue about improving quality of life and survival rates for individuals living with IPF. |
| format | Article |
| id | doaj-art-2c29587f2cfb41df946e697cfa551603 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-2c29587f2cfb41df946e697cfa5516032025-08-20T03:26:25ZengMDPI AGBiomedicines2227-90592025-06-01136136210.3390/biomedicines13061362Comorbidities’ Effect on IPF: Pathogenesis and ManagementAndrea Salotti0Maria Chianese1Antonio Romallo2Anna De Nes3Darina Angoni4Alessandra Galantino5Maria Chernovsky6Lucrezia Mondini7Francesco Salton8Paola Confalonieri9Rossella Cifaldi10Pietro Geri11Micol Pividori12Giulia Bandini13Michael Hughes14Marco Confalonieri15Marta Maggisano16Barbara Ruaro17Pulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyDepartment of Experimental and Clinical Medicine, Division of Internal Medicine, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50134 Florence, ItalyDivision of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester & Salford Royal NHS Foundation Trust, Manchester M6 8HD, UKPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyPulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, Hospital of Cattinara, 34149 Trieste, ItalyIn recent years, there has been a growing recognition within the medical community that idiopathic pulmonary fibrosis (IPF) cannot be effectively managed through a singular focus on the disease itself. Instead, a dual approach is essential, one that not only aims to prolong survival by targeting the underlying pathological mechanisms of IPF but also addresses the numerous comorbidities that frequently complicate the clinical picture for affected individuals. This narrative review seeks to provide a detailed and comprehensive exploration of the various comorbid conditions associated with IPF, which may include cardiovascular disease (CVD), lung cancer (LC), gastroesophageal reflux disease (GERD), obstructive sleep apnea (OSA), and anxiety/depression, among others. By understanding the interplay between these comorbidities and IPF, healthcare providers can better tailor treatment regimens to meet the holistic needs of patients. Furthermore, this review delves into both current management strategies and emerging therapeutic approaches for these comorbidities, emphasizing the importance of interdisciplinary collaboration in clinical practice. By synthesizing the latest research and clinical insights, this review aims to enhance awareness and understanding of the complexities surrounding IPF management, ultimately guiding clinicians in developing more effective, individualized care plans that address not only the fibrotic lung disease but also the broader spectrum of health challenges faced by patients. Through this comprehensive overview, we hope to contribute to the ongoing dialogue about improving quality of life and survival rates for individuals living with IPF.https://www.mdpi.com/2227-9059/13/6/1362idiopathic pulmonary fibrosis (IPF)comorbiditiespulmonary hypertensioncardiovascular diseaselung cancergastroesophageal reflux disease |
| spellingShingle | Andrea Salotti Maria Chianese Antonio Romallo Anna De Nes Darina Angoni Alessandra Galantino Maria Chernovsky Lucrezia Mondini Francesco Salton Paola Confalonieri Rossella Cifaldi Pietro Geri Micol Pividori Giulia Bandini Michael Hughes Marco Confalonieri Marta Maggisano Barbara Ruaro Comorbidities’ Effect on IPF: Pathogenesis and Management Biomedicines idiopathic pulmonary fibrosis (IPF) comorbidities pulmonary hypertension cardiovascular disease lung cancer gastroesophageal reflux disease |
| title | Comorbidities’ Effect on IPF: Pathogenesis and Management |
| title_full | Comorbidities’ Effect on IPF: Pathogenesis and Management |
| title_fullStr | Comorbidities’ Effect on IPF: Pathogenesis and Management |
| title_full_unstemmed | Comorbidities’ Effect on IPF: Pathogenesis and Management |
| title_short | Comorbidities’ Effect on IPF: Pathogenesis and Management |
| title_sort | comorbidities effect on ipf pathogenesis and management |
| topic | idiopathic pulmonary fibrosis (IPF) comorbidities pulmonary hypertension cardiovascular disease lung cancer gastroesophageal reflux disease |
| url | https://www.mdpi.com/2227-9059/13/6/1362 |
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