A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy
Monoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles in enhancing the immune system’s ability to recognise and eliminate tumour cells. These therapies are designed to either block inhibitory immune checkpoint pathways or to target specific tumour cell markers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antibodies |
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| Online Access: | https://www.mdpi.com/2073-4468/14/2/35 |
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| author | Angel Justiz-Vaillant Bijay Raj Pandit Chandrashekhar Unakal Sehlule Vuma Patrick Eberechi Akpaka |
| author_facet | Angel Justiz-Vaillant Bijay Raj Pandit Chandrashekhar Unakal Sehlule Vuma Patrick Eberechi Akpaka |
| author_sort | Angel Justiz-Vaillant |
| collection | DOAJ |
| description | Monoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles in enhancing the immune system’s ability to recognise and eliminate tumour cells. These therapies are designed to either block inhibitory immune checkpoint pathways or to target specific tumour cell markers for direct destruction. Additionally, mAbs can modulate the tumour microenvironment, enhance antibody-dependent cellular cytotoxicity, and inhibit angiogenesis, further amplifying their therapeutic impact. Below is a summary of monoclonal antibodies targeting key pathways, along with their indications and mechanisms of action, which are reviewed based on therapeutic mechanisms. |
| format | Article |
| id | doaj-art-2c248e7532fa4d45b58b5f7d0106a3dd |
| institution | Kabale University |
| issn | 2073-4468 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj-art-2c248e7532fa4d45b58b5f7d0106a3dd2025-08-20T03:26:15ZengMDPI AGAntibodies2073-44682025-04-011423510.3390/antib14020035A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer TherapyAngel Justiz-Vaillant0Bijay Raj Pandit1Chandrashekhar Unakal2Sehlule Vuma3Patrick Eberechi Akpaka4Department of Pathology/Microbiology & Pharmacology, The University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and TobagoDepartment of Pathology/Microbiology & Pharmacology, The University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and TobagoDepartment of Pathology/Microbiology & Pharmacology, The University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and TobagoDepartment of Pathology/Microbiology & Pharmacology, The University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and TobagoDepartment of Pathology/Microbiology & Pharmacology, The University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and TobagoMonoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles in enhancing the immune system’s ability to recognise and eliminate tumour cells. These therapies are designed to either block inhibitory immune checkpoint pathways or to target specific tumour cell markers for direct destruction. Additionally, mAbs can modulate the tumour microenvironment, enhance antibody-dependent cellular cytotoxicity, and inhibit angiogenesis, further amplifying their therapeutic impact. Below is a summary of monoclonal antibodies targeting key pathways, along with their indications and mechanisms of action, which are reviewed based on therapeutic mechanisms.https://www.mdpi.com/2073-4468/14/2/35monoclonal antibodyimmune cellssolid and haematological malignanciespersonalised medicine |
| spellingShingle | Angel Justiz-Vaillant Bijay Raj Pandit Chandrashekhar Unakal Sehlule Vuma Patrick Eberechi Akpaka A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy Antibodies monoclonal antibody immune cells solid and haematological malignancies personalised medicine |
| title | A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy |
| title_full | A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy |
| title_fullStr | A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy |
| title_full_unstemmed | A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy |
| title_short | A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy |
| title_sort | comprehensive review about the use of monoclonal antibodies in cancer therapy |
| topic | monoclonal antibody immune cells solid and haematological malignancies personalised medicine |
| url | https://www.mdpi.com/2073-4468/14/2/35 |
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