A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance

A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance

Abstract Background An important role for phenotype switching has been demonstrated in metastasis and therapeutic resistance of both melanoma and epithelial tumours. Phenotype switching in epithelial tumours is driven by a minority cancer stem cell (CSC) sub-population with lineage plasticity, but s...

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Main Authors: Olivia Knowles, Patricio Doldan, Isabella Hillier-Richardson, Sophia Lunetto, Stephanie Lunt, Gehad Youssef, Luke Gammon, Ian C. Mackenzie, Michael P. Philpott, Hasan Rizvi, Daniele Bergamaschi, Catherine A. Harwood, Adrian Biddle
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Melanoma
Cancer stem cells
CD24
Therapy resistance
Online Access:https://doi.org/10.1186/s12915-025-02336-2
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