Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation
The chick embryo chorioallantoic membrane (CAM) model is gaining increasing attention from cancer researchers worldwide. Its affordability, short experimental duration, robustness, and ease of tumor xenograft visualization make it a valuable tool in cancer research. This review explores recent advan...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-05-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL37456 |
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| author | Yuzhe Wang Wenyu Xue Margarita Pustovalova Denis V Kuzmin Sergey Leonov |
| author_facet | Yuzhe Wang Wenyu Xue Margarita Pustovalova Denis V Kuzmin Sergey Leonov |
| author_sort | Yuzhe Wang |
| collection | DOAJ |
| description | The chick embryo chorioallantoic membrane (CAM) model is gaining increasing attention from cancer researchers worldwide. Its affordability, short experimental duration, robustness, and ease of tumor xenograft visualization make it a valuable tool in cancer research. This review explores recent advancements and potential applications of the avian CAM model, including the following: (1) studying tumor growth and metastasis, (2) investigating mechanisms of tumor chemoresistance, (3) optimizing drug delivery methods, (4) improving bioimaging techniques, (5) evaluating immuno-oncology drug efficacy, (6) examining tumor-extracellular matrix interactions, (7) analyzing tumor angiogenesis, and (8) exploring the roles of microRNAs in cancer. Additionally, we compare the in ovo CAM model with other in vivo animal models and in vitro cell culture systems. Positioned between in vitro and in vivo models in terms of cost-effectiveness and accuracy in cancer recapitulation, the CAM model enhances both preclinical and translational research. Its expanding use in cancer studies and therapy development is expected to continue growing. |
| format | Article |
| id | doaj-art-2c1fe2de65b0443784c5062ce11737a8 |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-2c1fe2de65b0443784c5062ce11737a82025-08-20T03:24:48ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-05-013053745610.31083/FBL37456S2768-6701(25)01706-XChick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug EvaluationYuzhe Wang0Wenyu Xue1Margarita Pustovalova2Denis V Kuzmin3Sergey Leonov4Department of Cell Technologies, Institute of Future Biophysics, 141701 Dolgoprudny, RussiaDepartment of Cell Technologies, Institute of Future Biophysics, 141701 Dolgoprudny, RussiaDepartment of Cell Technologies, Institute of Future Biophysics, 141701 Dolgoprudny, RussiaSchool of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, RussiaDepartment of Cell Technologies, Institute of Future Biophysics, 141701 Dolgoprudny, RussiaThe chick embryo chorioallantoic membrane (CAM) model is gaining increasing attention from cancer researchers worldwide. Its affordability, short experimental duration, robustness, and ease of tumor xenograft visualization make it a valuable tool in cancer research. This review explores recent advancements and potential applications of the avian CAM model, including the following: (1) studying tumor growth and metastasis, (2) investigating mechanisms of tumor chemoresistance, (3) optimizing drug delivery methods, (4) improving bioimaging techniques, (5) evaluating immuno-oncology drug efficacy, (6) examining tumor-extracellular matrix interactions, (7) analyzing tumor angiogenesis, and (8) exploring the roles of microRNAs in cancer. Additionally, we compare the in ovo CAM model with other in vivo animal models and in vitro cell culture systems. Positioned between in vitro and in vivo models in terms of cost-effectiveness and accuracy in cancer recapitulation, the CAM model enhances both preclinical and translational research. Its expanding use in cancer studies and therapy development is expected to continue growing.https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL37456chick embryo chorioallantoic membrane (cam)in ovocancer metastasisdrug developmentradiotherapychemotherapymirnatumor-microenvironment interactionsimmuno-oncologyimmune-vascular dynamics |
| spellingShingle | Yuzhe Wang Wenyu Xue Margarita Pustovalova Denis V Kuzmin Sergey Leonov Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation Frontiers in Bioscience-Landmark chick embryo chorioallantoic membrane (cam) in ovo cancer metastasis drug development radiotherapy chemotherapy mirna tumor-microenvironment interactions immuno-oncology immune-vascular dynamics |
| title | Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation |
| title_full | Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation |
| title_fullStr | Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation |
| title_full_unstemmed | Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation |
| title_short | Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation |
| title_sort | chick embryo chorioallantoic membrane cam model for cancer studies and drug evaluation |
| topic | chick embryo chorioallantoic membrane (cam) in ovo cancer metastasis drug development radiotherapy chemotherapy mirna tumor-microenvironment interactions immuno-oncology immune-vascular dynamics |
| url | https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL37456 |
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