Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs
Currently, cancer is the leading cause of death globally. In the absence of specific treatment and early diagnosis, procedures like surgery, chemotherapy, and radiation therapy are often used to manage the disease. However, these approaches often fail to control cancer due to inefficacy, nonspecific...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Nano TransMed |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676024000116 |
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| author | Anil Kumar Grewal Raj Kumar Salar |
| author_facet | Anil Kumar Grewal Raj Kumar Salar |
| author_sort | Anil Kumar Grewal |
| collection | DOAJ |
| description | Currently, cancer is the leading cause of death globally. In the absence of specific treatment and early diagnosis, procedures like surgery, chemotherapy, and radiation therapy are often used to manage the disease. However, these approaches often fail to control cancer due to inefficacy, nonspecific distribution, and side effects of the drugs. Anticancer drugs are essential in reducing cancer cell growth and helping damage those cells. Anticancer drugs often cause severe side effects and have limited bioavailability due to their nonspecific distribution throughout the body. Therefore, the development of intelligent drug release systems is essential. Nanoparticle delivery systems are promising strategies to improve therapeutic efficacy and safety, overcoming challenges. Among these systems, a natural polysaccharide called chitosan, a derivative of chitin, has gained considerable attention as a biocompatible, biodegradable, and mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility of anticancer drugs, modulation of release kinetics, and biodistribution. Additionally, chitosan nanoparticles can be modified on their surface with ligands or stimuli-responsive moieties to achieve targeted delivery to specific cancer cells or tissues. This review explores recent advances in chitosan-based nanoparticle drug delivery, efficacy, and their applications in cancer therapy. |
| format | Article |
| id | doaj-art-2c1f2d7bbb88499a9cbb8eae73ec588a |
| institution | OA Journals |
| issn | 2790-6760 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-2c1f2d7bbb88499a9cbb8eae73ec588a2025-08-20T02:37:06ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602024-12-01310004010.1016/j.ntm.2024.100040Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugsAnil Kumar Grewal0Raj Kumar Salar1Department of Biotechnology Chaudhary Devi Lal University, Sirsa, 125055, IndiaCorresponding author.; Department of Biotechnology Chaudhary Devi Lal University, Sirsa, 125055, IndiaCurrently, cancer is the leading cause of death globally. In the absence of specific treatment and early diagnosis, procedures like surgery, chemotherapy, and radiation therapy are often used to manage the disease. However, these approaches often fail to control cancer due to inefficacy, nonspecific distribution, and side effects of the drugs. Anticancer drugs are essential in reducing cancer cell growth and helping damage those cells. Anticancer drugs often cause severe side effects and have limited bioavailability due to their nonspecific distribution throughout the body. Therefore, the development of intelligent drug release systems is essential. Nanoparticle delivery systems are promising strategies to improve therapeutic efficacy and safety, overcoming challenges. Among these systems, a natural polysaccharide called chitosan, a derivative of chitin, has gained considerable attention as a biocompatible, biodegradable, and mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility of anticancer drugs, modulation of release kinetics, and biodistribution. Additionally, chitosan nanoparticles can be modified on their surface with ligands or stimuli-responsive moieties to achieve targeted delivery to specific cancer cells or tissues. This review explores recent advances in chitosan-based nanoparticle drug delivery, efficacy, and their applications in cancer therapy.http://www.sciencedirect.com/science/article/pii/S2790676024000116Anticancer drugsChitosan nanoparticlesTargeted therapyCellular uptake |
| spellingShingle | Anil Kumar Grewal Raj Kumar Salar Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs Nano TransMed Anticancer drugs Chitosan nanoparticles Targeted therapy Cellular uptake |
| title | Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs |
| title_full | Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs |
| title_fullStr | Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs |
| title_full_unstemmed | Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs |
| title_short | Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs |
| title_sort | chitosan nanoparticle delivery systems an effective approach to enhancing efficacy and safety of anticancer drugs |
| topic | Anticancer drugs Chitosan nanoparticles Targeted therapy Cellular uptake |
| url | http://www.sciencedirect.com/science/article/pii/S2790676024000116 |
| work_keys_str_mv | AT anilkumargrewal chitosannanoparticledeliverysystemsaneffectiveapproachtoenhancingefficacyandsafetyofanticancerdrugs AT rajkumarsalar chitosannanoparticledeliverysystemsaneffectiveapproachtoenhancingefficacyandsafetyofanticancerdrugs |