Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities
Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent genomic instability, and immune evasion in tumor ce...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582166/full |
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| author | Xingchen Li Yidi Jia Yanqing Li Hu Hei Songtao Zhang Jianwu Qin |
| author_facet | Xingchen Li Yidi Jia Yanqing Li Hu Hei Songtao Zhang Jianwu Qin |
| author_sort | Xingchen Li |
| collection | DOAJ |
| description | Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent genomic instability, and immune evasion in tumor cells. The microbial community, known as “second genome” of human beings, can cause systemic disease by predisposing cells to tumors, and modulating immune responses to cancer. Metabolic reprogramming and microorganisms can crosstalk with each other in multiple ways to influence various physiological and pathological responses in cancer progression. The products of increased synthesis by tumor cells can reach the intestinal tract via the circulation and act on the microorganisms, promoting mucosal inflammation, causing systemic disorders, and may also regulate the immune response to cancer. In addition, the metabolites of the microorganisms can in turn be transported to the tumor microenvironment (TME) through the systemic circulation and participate in the process of tumor metabolic reprogramming. Different molecular mechanisms related to metabolic reprogramming and microbiota imbalance control the outcome of tumor or anti-tumor responses, depending on the type of cancer, stage of the disease and the TME. In this review, we focus on the fundamental role of metabolic reprogramming in the interaction between microorganisms and cancers and explore the molecular mechanisms by which metabolic reprogramming modulates this complex biological process. This comment aims to provide valuable resources for clinicians and researchers and promote further research in the field. |
| format | Article |
| id | doaj-art-2c18febe97e8419b9ade8d45ebfe4a3b |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-2c18febe97e8419b9ade8d45ebfe4a3b2025-08-20T01:52:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15821661582166Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunitiesXingchen Li0Yidi Jia1Yanqing Li2Hu Hei3Songtao Zhang4Jianwu Qin5Department of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaMetabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent genomic instability, and immune evasion in tumor cells. The microbial community, known as “second genome” of human beings, can cause systemic disease by predisposing cells to tumors, and modulating immune responses to cancer. Metabolic reprogramming and microorganisms can crosstalk with each other in multiple ways to influence various physiological and pathological responses in cancer progression. The products of increased synthesis by tumor cells can reach the intestinal tract via the circulation and act on the microorganisms, promoting mucosal inflammation, causing systemic disorders, and may also regulate the immune response to cancer. In addition, the metabolites of the microorganisms can in turn be transported to the tumor microenvironment (TME) through the systemic circulation and participate in the process of tumor metabolic reprogramming. Different molecular mechanisms related to metabolic reprogramming and microbiota imbalance control the outcome of tumor or anti-tumor responses, depending on the type of cancer, stage of the disease and the TME. In this review, we focus on the fundamental role of metabolic reprogramming in the interaction between microorganisms and cancers and explore the molecular mechanisms by which metabolic reprogramming modulates this complex biological process. This comment aims to provide valuable resources for clinicians and researchers and promote further research in the field.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582166/fullanti-tumor therapymetabolic reprogrammingmicrobiotatumor microenvironmentcancer progression |
| spellingShingle | Xingchen Li Yidi Jia Yanqing Li Hu Hei Songtao Zhang Jianwu Qin Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities Frontiers in Immunology anti-tumor therapy metabolic reprogramming microbiota tumor microenvironment cancer progression |
| title | Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities |
| title_full | Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities |
| title_fullStr | Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities |
| title_full_unstemmed | Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities |
| title_short | Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities |
| title_sort | crosstalk between metabolic reprogramming and microbiota implications for cancer progression and novel therapeutic opportunities |
| topic | anti-tumor therapy metabolic reprogramming microbiota tumor microenvironment cancer progression |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582166/full |
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