Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes
Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is considered the most toxic fumonisin produced by fungi and is commonly found in contaminated feed and crops. Fumonisin and its metabolites extensively exist in feed and crops, where FB<sub>1</sub>-polluted crop ingestion...
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MDPI AG
2025-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/17/5/239 |
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| author | Changyu Cao Weiping Hua Runxi Xian Yang Liu |
| author_facet | Changyu Cao Weiping Hua Runxi Xian Yang Liu |
| author_sort | Changyu Cao |
| collection | DOAJ |
| description | Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is considered the most toxic fumonisin produced by fungi and is commonly found in contaminated feed and crops. Fumonisin and its metabolites extensively exist in feed and crops, where FB<sub>1</sub>-polluted crop ingestion can do harm to livestock and poultry, causing poultry intestinal toxicity in the latter. For investigating FB<sub>1</sub>-mediated intestinal toxicity, we assessed the function of FB<sub>1</sub> exposure in quail intestines and explored its possible molecular mechanisms. In total, 120 quail pups were classified into two groups, where those in the control group were given a typical control diet, and those in the experimental group were given a typical diet that contained 30 mg/kg FB<sub>1</sub>. We evaluated the histopathological and ultrastructural changes in quails’ intestines on days 14, 28, and 42, and studied the molecular mechanisms by assessing oxidative stress, inflammation, and nuclear xenobiotic receptors (NXRs). Our results suggest that FB<sub>1</sub> exposure causes intestinal inflammation by triggering oxidative stress pathways and modulating NXRs to induce Cytochrome P450 proteins (CYP) isoforms, leading to intestinal histopathological damage. The results of this study shed novel light on the molecular mechanism underlying FB<sub>1</sub>-induced intestinal injury in juvenile quails. |
| format | Article |
| id | doaj-art-2c1420bca0544320a7b0d3b26ffc6958 |
| institution | OA Journals |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Toxins |
| spelling | doaj-art-2c1420bca0544320a7b0d3b26ffc69582025-08-20T02:33:48ZengMDPI AGToxins2072-66512025-05-0117523910.3390/toxins17050239Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP IsoenzymesChangyu Cao0Weiping Hua1Runxi Xian2Yang Liu3College of Animal Science and Technology, Foshan University, Foshan 528225, ChinaCollege of Animal Science and Technology, Foshan University, Foshan 528225, ChinaCollege of Animal Science and Technology, Foshan University, Foshan 528225, ChinaQuality Control Technical Center (Foshan) of National Famous and Special Agricultural Products (CAQS—GAP—KZZX043)/South China Food Safety Research Center, Foshan 528231, ChinaFumonisin B<sub>1</sub> (FB<sub>1</sub>) is considered the most toxic fumonisin produced by fungi and is commonly found in contaminated feed and crops. Fumonisin and its metabolites extensively exist in feed and crops, where FB<sub>1</sub>-polluted crop ingestion can do harm to livestock and poultry, causing poultry intestinal toxicity in the latter. For investigating FB<sub>1</sub>-mediated intestinal toxicity, we assessed the function of FB<sub>1</sub> exposure in quail intestines and explored its possible molecular mechanisms. In total, 120 quail pups were classified into two groups, where those in the control group were given a typical control diet, and those in the experimental group were given a typical diet that contained 30 mg/kg FB<sub>1</sub>. We evaluated the histopathological and ultrastructural changes in quails’ intestines on days 14, 28, and 42, and studied the molecular mechanisms by assessing oxidative stress, inflammation, and nuclear xenobiotic receptors (NXRs). Our results suggest that FB<sub>1</sub> exposure causes intestinal inflammation by triggering oxidative stress pathways and modulating NXRs to induce Cytochrome P450 proteins (CYP) isoforms, leading to intestinal histopathological damage. The results of this study shed novel light on the molecular mechanism underlying FB<sub>1</sub>-induced intestinal injury in juvenile quails.https://www.mdpi.com/2072-6651/17/5/239Fumonisin B<sub>1</sub>intestinaloxidative stressCytochrome P450 proteinsNXRs |
| spellingShingle | Changyu Cao Weiping Hua Runxi Xian Yang Liu Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes Toxins Fumonisin B<sub>1</sub> intestinal oxidative stress Cytochrome P450 proteins NXRs |
| title | Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes |
| title_full | Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes |
| title_fullStr | Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes |
| title_full_unstemmed | Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes |
| title_short | Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes |
| title_sort | fumonisin b sub 1 sub exposure causes intestinal tissue damage by triggering oxidative stress pathways and inducing associated cyp isoenzymes |
| topic | Fumonisin B<sub>1</sub> intestinal oxidative stress Cytochrome P450 proteins NXRs |
| url | https://www.mdpi.com/2072-6651/17/5/239 |
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