Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment
ABSTRACT Allergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine‐integrated pollen delivery system for the ACD treat...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-03-01
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| Series: | Smart Medicine |
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| Online Access: | https://doi.org/10.1002/smmd.136 |
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| author | Yuwei Wang Lijun Cai Yuanyuan Zhang Yan Cong Yuanjin Zhao |
| author_facet | Yuwei Wang Lijun Cai Yuanyuan Zhang Yan Cong Yuanjin Zhao |
| author_sort | Yuwei Wang |
| collection | DOAJ |
| description | ABSTRACT Allergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine‐integrated pollen delivery system for the ACD treatment. Sunflower pollens were collected and defatted to serve as adhesive drug carriers for matrine. Specifically, the exquisite porous and hollow structures of the pollen shells can absorb matrine and realize the sustained drug release. Besides, the prickly surface morphology can strongly adhere to the inflamed skin sites, which can prolong the duration of the drug. By utilizing them in an ACD model and an acute pruritus model of mice, we have demonstrated that these matrine‐integrated pollen shells can decrease the swelling degree of mice ears and weight loss, down‐regulate inflammatory response, and improve the scratching times. These results indicate that our matrine‐integrated pollen delivery systems have great potential to serve as natural topical preparations for skin disease therapy. |
| format | Article |
| id | doaj-art-2c140f33bc8d49078e0dc326f8bb711b |
| institution | OA Journals |
| issn | 2751-1871 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-2c140f33bc8d49078e0dc326f8bb711b2025-08-20T01:49:47ZengWiley-VCHSmart Medicine2751-18712025-03-0141n/an/a10.1002/smmd.136Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis TreatmentYuwei Wang0Lijun Cai1Yuanyuan Zhang2Yan Cong3Yuanjin Zhao4Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing ChinaSchool of Biological Science and Medical Engineering Southeast University Nanjing ChinaDepartment of Dermatology and Venereology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDepartment of Rheumatology and Immunology Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine Lianyungang ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing ChinaABSTRACT Allergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine‐integrated pollen delivery system for the ACD treatment. Sunflower pollens were collected and defatted to serve as adhesive drug carriers for matrine. Specifically, the exquisite porous and hollow structures of the pollen shells can absorb matrine and realize the sustained drug release. Besides, the prickly surface morphology can strongly adhere to the inflamed skin sites, which can prolong the duration of the drug. By utilizing them in an ACD model and an acute pruritus model of mice, we have demonstrated that these matrine‐integrated pollen shells can decrease the swelling degree of mice ears and weight loss, down‐regulate inflammatory response, and improve the scratching times. These results indicate that our matrine‐integrated pollen delivery systems have great potential to serve as natural topical preparations for skin disease therapy.https://doi.org/10.1002/smmd.136allergic contact dermatitisChinese medicinedrug deliverymatrinepollenskin disease |
| spellingShingle | Yuwei Wang Lijun Cai Yuanyuan Zhang Yan Cong Yuanjin Zhao Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment Smart Medicine allergic contact dermatitis Chinese medicine drug delivery matrine pollen skin disease |
| title | Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment |
| title_full | Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment |
| title_fullStr | Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment |
| title_full_unstemmed | Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment |
| title_short | Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment |
| title_sort | natural matrine integrated pollen delivery systems for allergic contact dermatitis treatment |
| topic | allergic contact dermatitis Chinese medicine drug delivery matrine pollen skin disease |
| url | https://doi.org/10.1002/smmd.136 |
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