Current Development of Virotherapy in Breast Cancer: A Brief Review
Breast cancer is the cancer with the greatest incidence in the world by 2020. This cancer has a high mortality rate, has the capability of metastasizing, and causes damage to important organs of the human body. Therefore, a lot of studies have been done to find the best therapy to overcome this prob...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-12-01
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| Series: | Acta Medica Bulgarica |
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| Online Access: | https://doi.org/10.2478/amb-2024-0084 |
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| author | Sasmana I. Putri P. Dewi N. Supadmanaba I. Wihandani D. |
| author_facet | Sasmana I. Putri P. Dewi N. Supadmanaba I. Wihandani D. |
| author_sort | Sasmana I. |
| collection | DOAJ |
| description | Breast cancer is the cancer with the greatest incidence in the world by 2020. This cancer has a high mortality rate, has the capability of metastasizing, and causes damage to important organs of the human body. Therefore, a lot of studies have been done to find the best therapy to overcome this problem. However, cancer has various special abilities that make it survive and continue to invade its host body, for example, the ability to evade its host immune system by several mechanisms. One of the potential cancer therapies is virotherapy. Virotherapy is a therapeutic method using viruses to destroy cancer cells. Several mechanisms can be provided by viruses, such as stimulating the host immune system and inducing apoptosis of cancer cells. Especially for breast cancer, there are 4 groups of viruses based on their genome that have oncolytic capability, such as the dsDNA, dsRNA, + ssRNA, and -ssRNA groups. Currently, there are several therapeutic virotherapy-based modalities for breast cancer that are in clinical trial phases. Each trial has shown positive results in developing virotherapy for breast cancer. |
| format | Article |
| id | doaj-art-2c131ff50b9c4adda4da30498f7e2def |
| institution | OA Journals |
| issn | 2719-5384 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj-art-2c131ff50b9c4adda4da30498f7e2def2025-08-20T01:53:33ZengSciendoActa Medica Bulgarica2719-53842024-12-01514869410.2478/amb-2024-0084Current Development of Virotherapy in Breast Cancer: A Brief ReviewSasmana I.0Putri P.1Dewi N.2Supadmanaba I.3Wihandani D.41Faculty of Medicine, Udayana University, Bali, Indonesia1Faculty of Medicine, Udayana University, Bali, Indonesia1Faculty of Medicine, Udayana University, Bali, Indonesia2Department of Biochemistry, Faculty of Medicine, Udayana University, Bali, Indonesia2Department of Biochemistry, Faculty of Medicine, Udayana University, Bali, IndonesiaBreast cancer is the cancer with the greatest incidence in the world by 2020. This cancer has a high mortality rate, has the capability of metastasizing, and causes damage to important organs of the human body. Therefore, a lot of studies have been done to find the best therapy to overcome this problem. However, cancer has various special abilities that make it survive and continue to invade its host body, for example, the ability to evade its host immune system by several mechanisms. One of the potential cancer therapies is virotherapy. Virotherapy is a therapeutic method using viruses to destroy cancer cells. Several mechanisms can be provided by viruses, such as stimulating the host immune system and inducing apoptosis of cancer cells. Especially for breast cancer, there are 4 groups of viruses based on their genome that have oncolytic capability, such as the dsDNA, dsRNA, + ssRNA, and -ssRNA groups. Currently, there are several therapeutic virotherapy-based modalities for breast cancer that are in clinical trial phases. Each trial has shown positive results in developing virotherapy for breast cancer.https://doi.org/10.2478/amb-2024-0084breast cancervirotherapypotential therapyimmunotherapyviruses |
| spellingShingle | Sasmana I. Putri P. Dewi N. Supadmanaba I. Wihandani D. Current Development of Virotherapy in Breast Cancer: A Brief Review Acta Medica Bulgarica breast cancer virotherapy potential therapy immunotherapy viruses |
| title | Current Development of Virotherapy in Breast Cancer: A Brief Review |
| title_full | Current Development of Virotherapy in Breast Cancer: A Brief Review |
| title_fullStr | Current Development of Virotherapy in Breast Cancer: A Brief Review |
| title_full_unstemmed | Current Development of Virotherapy in Breast Cancer: A Brief Review |
| title_short | Current Development of Virotherapy in Breast Cancer: A Brief Review |
| title_sort | current development of virotherapy in breast cancer a brief review |
| topic | breast cancer virotherapy potential therapy immunotherapy viruses |
| url | https://doi.org/10.2478/amb-2024-0084 |
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