Nuclear pore dysfunction and disease: a complex opportunity
The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including those related to the movement of material bet...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Nucleus |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19491034.2024.2314297 |
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| _version_ | 1850137980527706112 |
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| author | Charlotte M. Fare Jeffrey D. Rothstein |
| author_facet | Charlotte M. Fare Jeffrey D. Rothstein |
| author_sort | Charlotte M. Fare |
| collection | DOAJ |
| description | The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including those related to the movement of material between cellular compartments. In eukaryotic cells, nucleocytoplasmic trafficking is a fundamental biological process, and cumulative disruptions to nuclear integrity and nucleocytoplasmic transport are detrimental to cell survival. This is particularly true in post-mitotic neurons, where nuclear pore injury and errors to nucleocytoplasmic trafficking are strongly associated with neurodegenerative disease. In this review, we summarize the current understanding of nuclear pore biology in physiological and pathological contexts and discuss potential therapeutic approaches for addressing nuclear pore injury and dysfunctional nucleocytoplasmic transport. |
| format | Article |
| id | doaj-art-2c12c367ce224c1fba66e78eb8f949c3 |
| institution | OA Journals |
| issn | 1949-1034 1949-1042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nucleus |
| spelling | doaj-art-2c12c367ce224c1fba66e78eb8f949c32025-08-20T02:30:42ZengTaylor & Francis GroupNucleus1949-10341949-10422024-12-0115110.1080/19491034.2024.2314297Nuclear pore dysfunction and disease: a complex opportunityCharlotte M. Fare0Jeffrey D. Rothstein1Department of Neurology and Brain Science Institute, Johns Hopkins University, Baltimore, MD, USADepartment of Neurology and Brain Science Institute, Johns Hopkins University, Baltimore, MD, USAThe separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including those related to the movement of material between cellular compartments. In eukaryotic cells, nucleocytoplasmic trafficking is a fundamental biological process, and cumulative disruptions to nuclear integrity and nucleocytoplasmic transport are detrimental to cell survival. This is particularly true in post-mitotic neurons, where nuclear pore injury and errors to nucleocytoplasmic trafficking are strongly associated with neurodegenerative disease. In this review, we summarize the current understanding of nuclear pore biology in physiological and pathological contexts and discuss potential therapeutic approaches for addressing nuclear pore injury and dysfunctional nucleocytoplasmic transport.https://www.tandfonline.com/doi/10.1080/19491034.2024.2314297Neurodegenerative diseasenuclear pore complexnucleocytoplasmic transportnucleoporinnuclear envelopetherapeutics |
| spellingShingle | Charlotte M. Fare Jeffrey D. Rothstein Nuclear pore dysfunction and disease: a complex opportunity Nucleus Neurodegenerative disease nuclear pore complex nucleocytoplasmic transport nucleoporin nuclear envelope therapeutics |
| title | Nuclear pore dysfunction and disease: a complex opportunity |
| title_full | Nuclear pore dysfunction and disease: a complex opportunity |
| title_fullStr | Nuclear pore dysfunction and disease: a complex opportunity |
| title_full_unstemmed | Nuclear pore dysfunction and disease: a complex opportunity |
| title_short | Nuclear pore dysfunction and disease: a complex opportunity |
| title_sort | nuclear pore dysfunction and disease a complex opportunity |
| topic | Neurodegenerative disease nuclear pore complex nucleocytoplasmic transport nucleoporin nuclear envelope therapeutics |
| url | https://www.tandfonline.com/doi/10.1080/19491034.2024.2314297 |
| work_keys_str_mv | AT charlottemfare nuclearporedysfunctionanddiseaseacomplexopportunity AT jeffreydrothstein nuclearporedysfunctionanddiseaseacomplexopportunity |