Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia
OBJECTIVES To determine the frequency and risk factors of hematoma formation after bone marrow biopsy in patients with severe and very severe thrombocytopenia. METHODOLOGY This cross-sectional study was conducted at Hayatabad Medical Complex, Peshawar, from 1st April 2024 to 31st January 202...
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Gandhara University
2025-06-01
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| Series: | Journal of Gandhara Medical and Dental Sciences |
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| Online Access: | http://www.jgmds.org.pk/index.php/JGMDS/article/view/723 |
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| author | Ayesha Bangash Fawad Rahim Sheema Tariq Khushal Nadir Hadi Sobia Ahmed Qureshi Ayesha Hamid Gul E Lala Noman |
| author_facet | Ayesha Bangash Fawad Rahim Sheema Tariq Khushal Nadir Hadi Sobia Ahmed Qureshi Ayesha Hamid Gul E Lala Noman |
| author_sort | Ayesha Bangash |
| collection | DOAJ |
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OBJECTIVES
To determine the frequency and risk factors of hematoma formation after bone marrow biopsy in patients with severe and very severe thrombocytopenia.
METHODOLOGY
This cross-sectional study was conducted at Hayatabad Medical Complex, Peshawar, from 1st April 2024 to 31st January 2025. Patients over the age of 18 years with severe and very severe thrombocytopenia who underwent bone marrow biopsy were included. Age, gender, clinical bleeding at presentation, history of bone marrow biopsy at the same site, body mass index, and platelet count at the time of biopsy were documented. Participants were screened for hematoma twenty-four hours after the procedure. Data analysis was carried out in SPSS.
RESULTS
Most patients had severe thrombocytopenia (60.3%, n = 132), while the remaining patients had very severe thrombocytopenia (39.7%, n = 87). Only eight patients (3.7%) developed a hematoma. Patients who had clinical bleeding (95% CI: 1.93 – 168.45; p = 0.011) and who had repeat biopsy from a site of previous biopsy (AOR: 18.03; 95% CI: 1.93 – 168.45; p = 0.011) were significantly more likely to develop hematoma. The development of hematoma was not influenced by age, gender, body mass index, or the severity of thrombocytopenia.
CONCLUSION
Hematoma formation after bone marrow biopsy is uncommon. Patients with clinical bleeding and previous biopsy at the same site have a higher risk. Factors like age, gender, body mass index, and severity of thrombocytopenia did not significantly impact hematoma formation. Prophylactic platelet transfusion before bone marrow biopsy may largely be unnecessary and can be avoided.
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| format | Article |
| id | doaj-art-2c0927cbfadd41269098bfd2b159d4db |
| institution | OA Journals |
| issn | 2312-9433 2618-1452 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Gandhara University |
| record_format | Article |
| series | Journal of Gandhara Medical and Dental Sciences |
| spelling | doaj-art-2c0927cbfadd41269098bfd2b159d4db2025-08-20T02:37:49ZengGandhara UniversityJournal of Gandhara Medical and Dental Sciences2312-94332618-14522025-06-01123Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe ThrombocytopeniaAyesha Bangash0Fawad Rahim1Sheema Tariq2Khushal Nadir Hadi3Sobia Ahmed Qureshi4Ayesha Hamid5Gul E Lala Noman6Hayatabad Medical Complex, Peshawar Hayatabad Medical Complex / Khyber Girls Medical College, Peshawar.Hayatabad Medical Complex, PeshawarHayatabad Medical Complex, PeshawarHayatabad Medical Complex, PeshawarHayatabad Medical Complex, Peshawar, PakistanHayatabad Medical Complex, Peshawar OBJECTIVES To determine the frequency and risk factors of hematoma formation after bone marrow biopsy in patients with severe and very severe thrombocytopenia. METHODOLOGY This cross-sectional study was conducted at Hayatabad Medical Complex, Peshawar, from 1st April 2024 to 31st January 2025. Patients over the age of 18 years with severe and very severe thrombocytopenia who underwent bone marrow biopsy were included. Age, gender, clinical bleeding at presentation, history of bone marrow biopsy at the same site, body mass index, and platelet count at the time of biopsy were documented. Participants were screened for hematoma twenty-four hours after the procedure. Data analysis was carried out in SPSS. RESULTS Most patients had severe thrombocytopenia (60.3%, n = 132), while the remaining patients had very severe thrombocytopenia (39.7%, n = 87). Only eight patients (3.7%) developed a hematoma. Patients who had clinical bleeding (95% CI: 1.93 – 168.45; p = 0.011) and who had repeat biopsy from a site of previous biopsy (AOR: 18.03; 95% CI: 1.93 – 168.45; p = 0.011) were significantly more likely to develop hematoma. The development of hematoma was not influenced by age, gender, body mass index, or the severity of thrombocytopenia. CONCLUSION Hematoma formation after bone marrow biopsy is uncommon. Patients with clinical bleeding and previous biopsy at the same site have a higher risk. Factors like age, gender, body mass index, and severity of thrombocytopenia did not significantly impact hematoma formation. Prophylactic platelet transfusion before bone marrow biopsy may largely be unnecessary and can be avoided. http://www.jgmds.org.pk/index.php/JGMDS/article/view/723Bone marrowBiopsyThrombocytopeniaHematomaBleedingRisk factors |
| spellingShingle | Ayesha Bangash Fawad Rahim Sheema Tariq Khushal Nadir Hadi Sobia Ahmed Qureshi Ayesha Hamid Gul E Lala Noman Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia Journal of Gandhara Medical and Dental Sciences Bone marrow Biopsy Thrombocytopenia Hematoma Bleeding Risk factors |
| title | Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia |
| title_full | Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia |
| title_fullStr | Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia |
| title_full_unstemmed | Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia |
| title_short | Frequency and Risk Factors for Hematoma Formation Following Bone Marrow Biopsy in Patients with Severe and Very Severe Thrombocytopenia |
| title_sort | frequency and risk factors for hematoma formation following bone marrow biopsy in patients with severe and very severe thrombocytopenia |
| topic | Bone marrow Biopsy Thrombocytopenia Hematoma Bleeding Risk factors |
| url | http://www.jgmds.org.pk/index.php/JGMDS/article/view/723 |
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