Exosomes from Adipose-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw by Inhibiting Macrophage M1 Polarization and Pyroptosis

Exosomes from Adipose-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw by Inhibiting Macrophage M1 Polarization and Pyroptosis

Yi Zheng,1,2 Xinyu Wang,1 Yang He,1 Shuo Chen,1 Linhai He,1,3,&ast; Yi Zhang1,&ast; 1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China; 2Department of Stomatology, The First Affiliated Hospital, Zhe...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zheng Y, Wang X, He Y, Chen S, He L, Zhang Y
Format:	Article
Language:	English
Published:	Dove Medical Press 2024-11-01
Series:	International Journal of Nanomedicine
Subjects:	medication-related osteonecrosis of the jaw exosomes macrophage m1 polarization and pyroptosis primary wound healing nf-κb/nlrp3/il-1β axis
Online Access:	https://www.dovepress.com/exosomes-from-adipose-derived-mesenchymal-stromal-cells-prevent-medica-peer-reviewed-fulltext-article-IJN
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A case series and review of canine idiopathic osteonecrosis of the jaw
by: Amy Rossi, et al.
Published: (2025-05-01)

The role of stem cell-derived exosomes in regulating pyroptosis for disease therapy
by: Yilin Guo, et al.
Published: (2025-07-01)

ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium
by: Vittorio Fusco, et al.
Published: (2025-04-01)

Ibrutinib-associated osteonecrosis of the jaw
by: Annu Singh, et al.
Published: (2024-03-01)

Recent Stem-Cell-Based and Stem-Cell-Free Possibilities for the Therapeutic Management of the Osteonecrosis of the Jaw
by: Merita Mazreku, et al.
Published: (2025-04-01)

Bisphosphonate-related osteonecrosis of the jaw: An enigma among medical practitioners
by: Shalini Krishnan, et al.
Published: (2019-01-01)

Medication-related osteonecrosis of the jaws: a series of 22 cases highlighting their histopathological features
by: Dandara Andrade de SANTANA, et al.
Published: (2025-06-01)

Endodontic therapy and Medication-related osteonecrosis of the jaw onset: a scoping review and expert opinion-based qualitative meta-synthesis
by: R. Mauceri, et al.
Published: (2025-08-01)

Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells
by: Peizhuang Zhao, et al.
Published: (2024-12-01)

Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats
by: Felipe M. Silveira, et al.
Published: (2017-01-01)

Incidence of medication-related osteonecrosis of the jaw and associated antiresorptive drugs in adult Finnish population
by: Miika Kujanpää, et al.
Published: (2025-05-01)

Systematic Review on the Incidence of Bisphosphonate Related Osteonecrosis of the Jaw in Children Diagnosed with Osteogenesis Imperfecta
by: Anusha Adeline Hennedige, et al.
Published: (2014-01-01)

Effectiveness of Leukocyte- and Platelet-rich Fibrin in the Management of Medication-related Osteonecrosis of the Jaws – A Systematic Review
by: Rahul Mohandas, et al.
Published: (2024-01-01)

Neuralgia Inducing Cavitational Osteonecrosis of the Jaw: Scientific Controversy or pseudoscience?
by: Keith DA
Published: (2025-08-01)

Medication-related osteonecrosis of the jaw after dental clearance: Prevalence in an oncology center
by: Saad Hajeri, BDS, et al.
Published: (2022-09-01)

Surgical extraction with photobiomodulation as an adjunctive modality in patients at-risk for medication-related osteonecrosis of the jaw: retrospective study
by: Gianluca Tenore, et al.
Published: (2025-04-01)

Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis
by: Gavrić Miodrag, et al.
Published: (2014-01-01)

EPIDEMIOLOGICAL INVESTIGATION OF THE CLINICAL MANIFESTATION OF BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAWS IN 112 ONCOLOGY PATIENTS
by: Meri Hristamyan, et al.
Published: (2025-02-01)

Trueperella pyogenes promotes the synthesis and maturation of IL-1β in murine macrophages
by: Meimei Yang, et al.
Published: (2025-06-01)

The Application and Validity of a New Composite Radiographic Index for Patients with Osteonecrosis of the Jaws
by: Zafeiroula Yfanti, et al.
Published: (2025-04-01)

Pyroptosis and Oxidative Stress in Chronic Otitis Media
by: Müslüm Ayral, et al.
Published: (2025-03-01)

17(R)-RvD1 Ameliorates Liver Injury in Hyperuricemia Through Inhibiting Pyroptosis via NF-&kappa;B Signaling Pathway
by: Zhao L, et al.
Published: (2025-07-01)

The capsaicin receptor TRPV1 reduces sepsis-associated brain injury in mice by inhibiting pyroptosis
by: Menghong Long, et al.
Published: (2025-07-01)

Photobiomodulation in Medication-Related Osteonecrosis of the Jaw: Outcomes in Stage I and Its Adjunctive Role in Advanced Cases
by: Filip Michalak, et al.
Published: (2025-04-01)

Risk of Osteonecrosis of the Jaw in Patients Treated with Zoledronic or Alendronic Acid: A Systematic Review
by: Aine Jakonyte, et al.
Published: (2025-06-01)

Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis
by: Yao S, et al.
Published: (2025-04-01)

Regulation of pyroptosis by NF-κB signaling
by: Ling Yang, et al.
Published: (2025-01-01)

Osteonecrosis of the jaw associated with ustekinumab in the treatment of Crohn's disease
by: Jean Massaad, et al.
Published: (2024-10-01)

Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis
by: James Olutayo, et al.
Published: (2010-04-01)

Education and Communication on the Topic of Osteonecrosis of the Jaw When Taking Bone‐Stabilizing Drugs
by: Franz Gustav Saur, et al.
Published: (2024-12-01)

Clinical and Histological Evaluation of Jaw Osteonecrosis Unrelated to Anti-Bone Resorption Drugs
by: Cinzia Casu, et al.
Published: (2025-04-01)

Occlusive denture for the management of medication-related osteonecrosis of the jaw with oronasal communication: A case report
by: Arthur Augusto Martins e Silva, et al.
Published: (2025-06-01)

Systemic Ozone Therapy Improves Oral Hard and Soft Tissue Healing in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Study in Senescent Female Rats
by: Leonardo Alan Delanora, et al.
Published: (2025-05-01)

Quantitative indices for cone-beam CT assessment of Medication-Related Osteonecrosis of the Jaw – a scoping review
by: Ghaidaa Badabaan, et al.
Published: (2023-02-01)

Mechanisms of pyroptosis in modulating osteoblast function under simulated microgravity
by: Min Wang, et al.
Published: (2025-04-01)

Exosomes secreted from human-derived adipose stem cells prevent progression of osteonecrosis of the femoral head
by: Tatsuhito Ikezaki, et al.
Published: (2024-11-01)

Experimental study of the effect of teriparatide on a medication-related rat model of osteonecrosis of the jaw
by: LIAO Chenyu, et al.
Published: (2024-02-01)

Novel modified quantitative index for cone-beam CT assessment of medication-related osteonecrosis of the jaw - comparative analysis with original index
by: Ghaidaa Badabaan, et al.
Published: (2023-05-01)

Platelet Rich Fibrin (PRF) in the Management of Osteonecrosis of the Jaw: A Narrative Review
by: A F M Shakilur Rahman
Published: (2025-04-01)

Comparison of the Effectiveness of Conservative and Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: a Systematic Review
by: Rial Seluki, et al.
Published: (2023-12-01)