177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer
Internal radionuclide therapy using lutetium‐177 (177Lu)‐based radiopharmaceuticals has emerged as a promising approach in the field of nuclear medicine and oncology. Combining the radioactive lanthanide with high atomic number metal nanoparticles such as gold potentiates the radiotoxicity of luteti...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-05-01
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| Series: | Small Science |
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| Online Access: | https://doi.org/10.1002/smsc.202400550 |
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| author | Mathilde Ponchelle Marek Pruszyński Edmond Gravel Eric Doris |
| author_facet | Mathilde Ponchelle Marek Pruszyński Edmond Gravel Eric Doris |
| author_sort | Mathilde Ponchelle |
| collection | DOAJ |
| description | Internal radionuclide therapy using lutetium‐177 (177Lu)‐based radiopharmaceuticals has emerged as a promising approach in the field of nuclear medicine and oncology. Combining the radioactive lanthanide with high atomic number metal nanoparticles such as gold potentiates the radiotoxicity of lutetium by an amplification process. 177Lu‐gold nanohybrids have been investigated by various research groups, both in vitro and in vivo, to decipher the physicochemical, radiochemical, and biological factors that would enable selective and optimal dose deposition in tumors. This review focuses on 177Lu‐gold tailored approaches that are developed in the literature to locally enhance internal radiotherapeutic effects. |
| format | Article |
| id | doaj-art-2bfce3779b6d444691ac6a862f34fa6b |
| institution | Kabale University |
| issn | 2688-4046 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj-art-2bfce3779b6d444691ac6a862f34fa6b2025-08-20T03:52:29ZengWiley-VCHSmall Science2688-40462025-05-0155n/an/a10.1002/smsc.202400550177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against CancerMathilde Ponchelle0Marek Pruszyński1Edmond Gravel2Eric Doris3Université Paris‐Saclay, CEA, INRAE Département Médicaments et Technologies pour la Santé (DMTS), SCBM 91191 Gif‐sur‐Yvette FranceNOMATEN Centre of Excellence National Centre for Nuclear Research 05‐400 Otwock PolandUniversité Paris‐Saclay, CEA, INRAE Département Médicaments et Technologies pour la Santé (DMTS), SCBM 91191 Gif‐sur‐Yvette FranceUniversité Paris‐Saclay, CEA, INRAE Département Médicaments et Technologies pour la Santé (DMTS), SCBM 91191 Gif‐sur‐Yvette FranceInternal radionuclide therapy using lutetium‐177 (177Lu)‐based radiopharmaceuticals has emerged as a promising approach in the field of nuclear medicine and oncology. Combining the radioactive lanthanide with high atomic number metal nanoparticles such as gold potentiates the radiotoxicity of lutetium by an amplification process. 177Lu‐gold nanohybrids have been investigated by various research groups, both in vitro and in vivo, to decipher the physicochemical, radiochemical, and biological factors that would enable selective and optimal dose deposition in tumors. This review focuses on 177Lu‐gold tailored approaches that are developed in the literature to locally enhance internal radiotherapeutic effects.https://doi.org/10.1002/smsc.202400550gold nanoparticleslutetium‐177nanomedicinesradioenhancementradiopharmaceuticals |
| spellingShingle | Mathilde Ponchelle Marek Pruszyński Edmond Gravel Eric Doris 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer Small Science gold nanoparticles lutetium‐177 nanomedicines radioenhancement radiopharmaceuticals |
| title | 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer |
| title_full | 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer |
| title_fullStr | 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer |
| title_full_unstemmed | 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer |
| title_short | 177Lu‐Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer |
| title_sort | 177lu gold nanohybrids in radiotherapeutic approaches against cancer |
| topic | gold nanoparticles lutetium‐177 nanomedicines radioenhancement radiopharmaceuticals |
| url | https://doi.org/10.1002/smsc.202400550 |
| work_keys_str_mv | AT mathildeponchelle 177lugoldnanohybridsinradiotherapeuticapproachesagainstcancer AT marekpruszynski 177lugoldnanohybridsinradiotherapeuticapproachesagainstcancer AT edmondgravel 177lugoldnanohybridsinradiotherapeuticapproachesagainstcancer AT ericdoris 177lugoldnanohybridsinradiotherapeuticapproachesagainstcancer |