A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report
Abstract Background Multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma (DLBCL) are rare. Here, we report a case of advanced breast cancer and DLBCL managed with multidisciplinary therapy preceded by surgery with a successful outcome. Case presentation During a medical e...
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| Language: | English |
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Japan Surgical Society
2022-05-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-022-01456-z |
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| author | Yuichi Ueda Yuko Makino Taro Tochigi Yoshikazu Ota Hideki Hidaka Takeshi Nakamura Kiichiro Beppu Jiro Ohuchida Seiichi Odate Soshi Terasaka Takahiro Nishida Masaki Yoshida Ryuichiro Kimura Kousuke Marutsuka Naoki Otomo |
| author_facet | Yuichi Ueda Yuko Makino Taro Tochigi Yoshikazu Ota Hideki Hidaka Takeshi Nakamura Kiichiro Beppu Jiro Ohuchida Seiichi Odate Soshi Terasaka Takahiro Nishida Masaki Yoshida Ryuichiro Kimura Kousuke Marutsuka Naoki Otomo |
| author_sort | Yuichi Ueda |
| collection | DOAJ |
| description | Abstract Background Multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma (DLBCL) are rare. Here, we report a case of advanced breast cancer and DLBCL managed with multidisciplinary therapy preceded by surgery with a successful outcome. Case presentation During a medical examination, a 71-year-old woman was diagnosed with a right breast mass, enlarged lymph nodes throughout the body, and a splenic tumor. The results of the clinical examination and imaging were suggestive of widely spread breast cancer with lymph node metastasis and malignant lymphoma with systemic metastasis. The histological evaluation of the biopsied breast tissue revealed human epidermal growth factor receptor 2 (HER2)-positive breast cancer, whereas the histological evaluation of the excised inguinal lymph node revealed DLBCL. 18F-FDG PET/computed tomography was performed, and it was determined that both breast cancer and DLBCL were in an advanced stage. Thus, mastectomy was performed, and the axillary lymph nodes showed mixed metastasis of breast cancer and DLBCL. Soon after, the R-CHOP therapy was initiated (375-mg/m2 rituximab, 2-mg/m2 vincristine, 50-mg/m2 doxorubicin, 750-mg/m2 cyclophosphamide, and 125-mg methylprednisolone). After irradiation of the spleen, trastuzumab was administered for 1 year. Conclusions We experienced a case of combined breast cancer and DLBCL, which was difficult to treat because both were in advanced stages. Thorough staging of the malignancy and discussion by a multidisciplinary team are necessary to determine the optimal treatment strategy. |
| format | Article |
| id | doaj-art-2bfc09f386c84c4889f8425cacf5c599 |
| institution | OA Journals |
| issn | 2198-7793 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-2bfc09f386c84c4889f8425cacf5c5992025-08-20T02:37:28ZengJapan Surgical SocietySurgical Case Reports2198-77932022-05-01811710.1186/s40792-022-01456-zA rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case reportYuichi Ueda0Yuko Makino1Taro Tochigi2Yoshikazu Ota3Hideki Hidaka4Takeshi Nakamura5Kiichiro Beppu6Jiro Ohuchida7Seiichi Odate8Soshi Terasaka9Takahiro Nishida10Masaki Yoshida11Ryuichiro Kimura12Kousuke Marutsuka13Naoki Otomo14Department of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki HospitalMedical City Tobu HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalDepartment of Diagnostic Pathology, Miyazaki Prefectural Miyazaki HospitalDepartment of Surgery, Miyazaki Prefectural Miyazaki HospitalAbstract Background Multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma (DLBCL) are rare. Here, we report a case of advanced breast cancer and DLBCL managed with multidisciplinary therapy preceded by surgery with a successful outcome. Case presentation During a medical examination, a 71-year-old woman was diagnosed with a right breast mass, enlarged lymph nodes throughout the body, and a splenic tumor. The results of the clinical examination and imaging were suggestive of widely spread breast cancer with lymph node metastasis and malignant lymphoma with systemic metastasis. The histological evaluation of the biopsied breast tissue revealed human epidermal growth factor receptor 2 (HER2)-positive breast cancer, whereas the histological evaluation of the excised inguinal lymph node revealed DLBCL. 18F-FDG PET/computed tomography was performed, and it was determined that both breast cancer and DLBCL were in an advanced stage. Thus, mastectomy was performed, and the axillary lymph nodes showed mixed metastasis of breast cancer and DLBCL. Soon after, the R-CHOP therapy was initiated (375-mg/m2 rituximab, 2-mg/m2 vincristine, 50-mg/m2 doxorubicin, 750-mg/m2 cyclophosphamide, and 125-mg methylprednisolone). After irradiation of the spleen, trastuzumab was administered for 1 year. Conclusions We experienced a case of combined breast cancer and DLBCL, which was difficult to treat because both were in advanced stages. Thorough staging of the malignancy and discussion by a multidisciplinary team are necessary to determine the optimal treatment strategy.https://doi.org/10.1186/s40792-022-01456-zMultiple primary malignanciesDouble cancerSynchronousBreast cancerDLBCL |
| spellingShingle | Yuichi Ueda Yuko Makino Taro Tochigi Yoshikazu Ota Hideki Hidaka Takeshi Nakamura Kiichiro Beppu Jiro Ohuchida Seiichi Odate Soshi Terasaka Takahiro Nishida Masaki Yoshida Ryuichiro Kimura Kousuke Marutsuka Naoki Otomo A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report Surgical Case Reports Multiple primary malignancies Double cancer Synchronous Breast cancer DLBCL |
| title | A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report |
| title_full | A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report |
| title_fullStr | A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report |
| title_full_unstemmed | A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report |
| title_short | A rare case of synchronous multiple primary malignancies of breast cancer and diffuse large B-cell lymphoma that responded to multidisciplinary treatment: a case report |
| title_sort | rare case of synchronous multiple primary malignancies of breast cancer and diffuse large b cell lymphoma that responded to multidisciplinary treatment a case report |
| topic | Multiple primary malignancies Double cancer Synchronous Breast cancer DLBCL |
| url | https://doi.org/10.1186/s40792-022-01456-z |
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