Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation
Diabetic kidney disease (DKD), a major microvascular complication of diabetes, is closely associated with functional imbalances in ion channels regulating sodium (Na+), calcium (Ca2+), potassium (K+), and chloride (Cl–). This review systematically examines the roles of ion channels in glomerular fil...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1607701/full |
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| author | Wenfeng Wang Bi Ke Chen Wang Xiaojing Xiong Xiuyuan Feng Hua Yan |
| author_facet | Wenfeng Wang Bi Ke Chen Wang Xiaojing Xiong Xiuyuan Feng Hua Yan |
| author_sort | Wenfeng Wang |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD), a major microvascular complication of diabetes, is closely associated with functional imbalances in ion channels regulating sodium (Na+), calcium (Ca2+), potassium (K+), and chloride (Cl–). This review systematically examines the roles of ion channels in glomerular filtration barrier dysfunction, tubular reabsorption, and fibrotic processes in DKD, with emphasis on the pathological relevance of sodium-glucose cotransporter 2 (SGLT2), epithelial sodium channels (ENaC), transient receptor potential (TRP) channels, chloride channels, aquaporins (AQPs), and PIEZO channels. We further evaluate the clinical efficacy and challenges of ion channel-targeted therapies, including SGLT2 inhibitors and mineralocorticoid receptor antagonists. Emerging strategies integrating ion channel omics, machine learning, engineered biomaterials, and exosome-based delivery systems are proposed to shift DKD treatment paradigms from disease progression delay to pathological reversal. Interdisciplinary collaboration is critical to achieving personalized precision medicine, offering novel perspectives for DKD diagnosis and management. |
| format | Article |
| id | doaj-art-2bfaff70abba4b3797ef8870d5dbef63 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-2bfaff70abba4b3797ef8870d5dbef632025-08-20T03:27:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.16077011607701Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovationWenfeng Wang0Bi Ke1Chen Wang2Xiaojing Xiong3Xiuyuan Feng4Hua Yan5Department of Cardiology, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Cardiology, Ezhou Central Hospital, Ezhou, Hubei, ChinaDepartment of Cardiology, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Cardiology, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Cardiology, Ezhou Central Hospital, Ezhou, Hubei, ChinaDepartment of Cardiology, Ezhou Central Hospital, Ezhou, Hubei, ChinaDiabetic kidney disease (DKD), a major microvascular complication of diabetes, is closely associated with functional imbalances in ion channels regulating sodium (Na+), calcium (Ca2+), potassium (K+), and chloride (Cl–). This review systematically examines the roles of ion channels in glomerular filtration barrier dysfunction, tubular reabsorption, and fibrotic processes in DKD, with emphasis on the pathological relevance of sodium-glucose cotransporter 2 (SGLT2), epithelial sodium channels (ENaC), transient receptor potential (TRP) channels, chloride channels, aquaporins (AQPs), and PIEZO channels. We further evaluate the clinical efficacy and challenges of ion channel-targeted therapies, including SGLT2 inhibitors and mineralocorticoid receptor antagonists. Emerging strategies integrating ion channel omics, machine learning, engineered biomaterials, and exosome-based delivery systems are proposed to shift DKD treatment paradigms from disease progression delay to pathological reversal. Interdisciplinary collaboration is critical to achieving personalized precision medicine, offering novel perspectives for DKD diagnosis and management.https://www.frontiersin.org/articles/10.3389/fmed.2025.1607701/fullion channelsdiabetic kidney diseasetargeted therapyprecision medicinesodium-glucose cotransporter 2 |
| spellingShingle | Wenfeng Wang Bi Ke Chen Wang Xiaojing Xiong Xiuyuan Feng Hua Yan Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation Frontiers in Medicine ion channels diabetic kidney disease targeted therapy precision medicine sodium-glucose cotransporter 2 |
| title | Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation |
| title_full | Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation |
| title_fullStr | Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation |
| title_full_unstemmed | Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation |
| title_short | Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation |
| title_sort | targeting ion channel networks in diabetic kidney disease from molecular crosstalk to precision therapeutics and clinical innovation |
| topic | ion channels diabetic kidney disease targeted therapy precision medicine sodium-glucose cotransporter 2 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1607701/full |
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