Defining polypharmacy in the elderly: a systematic review protocol
Introduction Ageing—along with its associated physiological and pathological changes—places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the eld...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2016-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/6/3/e010989.full |
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| author | Seyede Salehe Mortazavi Mohsen Shati Seyed Kazem Malakouti Abasali Keshtkar Mohsen Bazargan Shervin Assari |
| author_facet | Seyede Salehe Mortazavi Mohsen Shati Seyed Kazem Malakouti Abasali Keshtkar Mohsen Bazargan Shervin Assari |
| author_sort | Seyede Salehe Mortazavi |
| collection | DOAJ |
| description | Introduction Ageing—along with its associated physiological and pathological changes—places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all populations. In recent decades, several scientific investigations have studied polypharmacy and its correlates, using different approaches and definitions, and their results have been inconclusive. Differences in definitions and approaches in these studies form a barrier against reaching a conclusion regarding the risk factors and consequences of polypharmacy. It is therefore imperative to establish an appropriate definition of polypharmacy.Methods and analysis A systematic review will be conducted using PubMed, Scopus, Web of Science, EMBASE, PsycINFO and AgeLine bibliographic databases, as well as the grey literature on polypharmacy in older adults to answer these two questions: What definitions in the literature are being used for polypharmacy in older people?, and Which definitions are more comprehensive and applicable? 2 independent reviewers will conduct the primary screening of the articles and data extraction, and eligible sources will be selected after discussing non-conformities. All extracted data from selected articles will be categorised based on the type of study participants, study design and setting, the methodological quality of primary studies and any other potential source of heterogeneity, and results will be summarised in a table, which will contain the levels of evidence and methodological quality of the included studies. The most comprehensive definition of polypharmacy will be selected from the final list of definitions through an international expert webinar.Ethics and Dissemination This research is exempt from ethics approval because the work is carried out on published documents. We will disseminate this protocol in a related peer-reviewed journal. |
| format | Article |
| id | doaj-art-2bfab7e4da294d0989352dbb8ac055da |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2bfab7e4da294d0989352dbb8ac055da2025-02-12T02:40:09ZengBMJ Publishing GroupBMJ Open2044-60552016-03-016310.1136/bmjopen-2015-010989Defining polypharmacy in the elderly: a systematic review protocolSeyede Salehe Mortazavi0Mohsen Shati1Seyed Kazem Malakouti2Abasali Keshtkar3Mohsen Bazargan4Shervin Assari51Mental Health Research Center, Tehran Institute of Psychiatry–School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran2Department of Aging, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran1Mental Health Research Center, Tehran Institute of Psychiatry–School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran3Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran4Department of Family Medicine, Charles R Drew University of Medicine and Science, Los Angeles, USADepartment of Family Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USAIntroduction Ageing—along with its associated physiological and pathological changes—places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all populations. In recent decades, several scientific investigations have studied polypharmacy and its correlates, using different approaches and definitions, and their results have been inconclusive. Differences in definitions and approaches in these studies form a barrier against reaching a conclusion regarding the risk factors and consequences of polypharmacy. It is therefore imperative to establish an appropriate definition of polypharmacy.Methods and analysis A systematic review will be conducted using PubMed, Scopus, Web of Science, EMBASE, PsycINFO and AgeLine bibliographic databases, as well as the grey literature on polypharmacy in older adults to answer these two questions: What definitions in the literature are being used for polypharmacy in older people?, and Which definitions are more comprehensive and applicable? 2 independent reviewers will conduct the primary screening of the articles and data extraction, and eligible sources will be selected after discussing non-conformities. All extracted data from selected articles will be categorised based on the type of study participants, study design and setting, the methodological quality of primary studies and any other potential source of heterogeneity, and results will be summarised in a table, which will contain the levels of evidence and methodological quality of the included studies. The most comprehensive definition of polypharmacy will be selected from the final list of definitions through an international expert webinar.Ethics and Dissemination This research is exempt from ethics approval because the work is carried out on published documents. We will disseminate this protocol in a related peer-reviewed journal.https://bmjopen.bmj.com/content/6/3/e010989.full |
| spellingShingle | Seyede Salehe Mortazavi Mohsen Shati Seyed Kazem Malakouti Abasali Keshtkar Mohsen Bazargan Shervin Assari Defining polypharmacy in the elderly: a systematic review protocol BMJ Open |
| title | Defining polypharmacy in the elderly: a systematic review protocol |
| title_full | Defining polypharmacy in the elderly: a systematic review protocol |
| title_fullStr | Defining polypharmacy in the elderly: a systematic review protocol |
| title_full_unstemmed | Defining polypharmacy in the elderly: a systematic review protocol |
| title_short | Defining polypharmacy in the elderly: a systematic review protocol |
| title_sort | defining polypharmacy in the elderly a systematic review protocol |
| url | https://bmjopen.bmj.com/content/6/3/e010989.full |
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