Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt
Objectives: To study the epidemiological and demographic data of retinopathy of prematurity (ROP) as well as the effectiveness of intravitreal injection of bevacizumab (IVB) as monotherapy for type I ROP in a local neonatal intensive care unit in Egypt. Methods: An observational study, where the med...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Dr. Sulaiman Al Habib Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/DSHMJ.DSHMJ_33_24 |
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| author | Ehab Mohamed Hantash Abdulrahman Abdullah Al Zahrani Yasser Ragab Serag |
| author_facet | Ehab Mohamed Hantash Abdulrahman Abdullah Al Zahrani Yasser Ragab Serag |
| author_sort | Ehab Mohamed Hantash |
| collection | DOAJ |
| description | Objectives:
To study the epidemiological and demographic data of retinopathy of prematurity (ROP) as well as the effectiveness of intravitreal injection of bevacizumab (IVB) as monotherapy for type I ROP in a local neonatal intensive care unit in Egypt.
Methods:
An observational study, where the medical records of all babies eligible for ROP screening over a period of 12 months (2020–2021) were reviewed. The screening results were reported in stage, zone, extent, and plus disease. Babies with type 1 ROP were eligible for treatment with IVB. Their medical files were reviewed for possible risk factors associated with ROP. The primary outcomes were the presence or absence of ROP, eligibility for IVB, complications of IVB and regression or recurrence of ROP.
Results:
ROP affects a significant proportion of babies (55%). The lower the birth weight (and accordingly, the gestational age [GA]), the higher the incidence of ROP. Recurrent apnea, mechanical ventilation, and continuous positive airway pressure were associated with a significant risk for ROP. On the other hand, nasal cannula, sepsis, and blood transfusion did not significantly increase the risk of ROP. Although common, most cases (48.6%) had type 2 ROP and only required follow-up. IVB was effective and safe in arresting disease progression in 93% of the remaining patients with type 1 ROP (6.4%).
Conclusion:
ROP is a significant cause of morbidity in preterm babies in Egypt. Low birth weight, apnea, and respiratory support are significant risk factors. Most cases are mild and only require follow-up. Up to 6.4% of the cases had type 1 ROP. Monotherapy with IVB appears to be effective and safe. Neonatal care has to be optimized to further reduce the current incidence rate of ROP. |
| format | Article |
| id | doaj-art-2bf98535ce2c4f48a3bb2b8fb7d119da |
| institution | Kabale University |
| issn | 2666-819X 2590-3349 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dr. Sulaiman Al Habib Medical Journal |
| spelling | doaj-art-2bf98535ce2c4f48a3bb2b8fb7d119da2025-08-21T04:59:25ZengWolters Kluwer Medknow PublicationsDr. Sulaiman Al Habib Medical Journal2666-819X2590-33492024-04-0162667210.4103/DSHMJ.DSHMJ_33_24Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in EgyptEhab Mohamed HantashAbdulrahman Abdullah Al ZahraniYasser Ragab SeragObjectives: To study the epidemiological and demographic data of retinopathy of prematurity (ROP) as well as the effectiveness of intravitreal injection of bevacizumab (IVB) as monotherapy for type I ROP in a local neonatal intensive care unit in Egypt. Methods: An observational study, where the medical records of all babies eligible for ROP screening over a period of 12 months (2020–2021) were reviewed. The screening results were reported in stage, zone, extent, and plus disease. Babies with type 1 ROP were eligible for treatment with IVB. Their medical files were reviewed for possible risk factors associated with ROP. The primary outcomes were the presence or absence of ROP, eligibility for IVB, complications of IVB and regression or recurrence of ROP. Results: ROP affects a significant proportion of babies (55%). The lower the birth weight (and accordingly, the gestational age [GA]), the higher the incidence of ROP. Recurrent apnea, mechanical ventilation, and continuous positive airway pressure were associated with a significant risk for ROP. On the other hand, nasal cannula, sepsis, and blood transfusion did not significantly increase the risk of ROP. Although common, most cases (48.6%) had type 2 ROP and only required follow-up. IVB was effective and safe in arresting disease progression in 93% of the remaining patients with type 1 ROP (6.4%). Conclusion: ROP is a significant cause of morbidity in preterm babies in Egypt. Low birth weight, apnea, and respiratory support are significant risk factors. Most cases are mild and only require follow-up. Up to 6.4% of the cases had type 1 ROP. Monotherapy with IVB appears to be effective and safe. Neonatal care has to be optimized to further reduce the current incidence rate of ROP.https://journals.lww.com/10.4103/DSHMJ.DSHMJ_33_24bevacizumablow birth weightpretermretinopathy of prematurity |
| spellingShingle | Ehab Mohamed Hantash Abdulrahman Abdullah Al Zahrani Yasser Ragab Serag Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt Dr. Sulaiman Al Habib Medical Journal bevacizumab low birth weight preterm retinopathy of prematurity |
| title | Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt |
| title_full | Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt |
| title_fullStr | Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt |
| title_full_unstemmed | Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt |
| title_short | Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt |
| title_sort | retinopathy of prematurity rop risk factors and therapeutic effect of intravitreal injection of bevacizumab ivb an observational study from a neonatal intensive care unit in egypt |
| topic | bevacizumab low birth weight preterm retinopathy of prematurity |
| url | https://journals.lww.com/10.4103/DSHMJ.DSHMJ_33_24 |
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