Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis
The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic re...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/959746 |
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| _version_ | 1832563136083787776 |
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| author | Charles H. Halsted Valentina Medici |
| author_facet | Charles H. Halsted Valentina Medici |
| author_sort | Charles H. Halsted |
| collection | DOAJ |
| description | The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of genes relevant to liver injury. The present paper describes the effects of ethanol on the hepatic methionine cycle, followed by evidence for the central role of reduced SAM in the pathogenesis of ASH according to clinical data and experiments in ethanol-fed animals and in cell models. The efficacy of supplemental SAM in the prevention of ASH in animal models and in the clinical treatment of ASH will be discussed. |
| format | Article |
| id | doaj-art-2bf2ced35c6b430c9ad582923444fbff |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-2bf2ced35c6b430c9ad582923444fbff2025-02-03T01:20:54ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/959746959746Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic SteatohepatitisCharles H. Halsted0Valentina Medici1Department of Internal Medicine, University of California, Davis, 451 E. Health Sciences Drive, Room 6323, Davis, CA 95616, USADepartment of Internal Medicine, University of California, Davis, 451 E. Health Sciences Drive, Room 6323, Davis, CA 95616, USAThe pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of genes relevant to liver injury. The present paper describes the effects of ethanol on the hepatic methionine cycle, followed by evidence for the central role of reduced SAM in the pathogenesis of ASH according to clinical data and experiments in ethanol-fed animals and in cell models. The efficacy of supplemental SAM in the prevention of ASH in animal models and in the clinical treatment of ASH will be discussed.http://dx.doi.org/10.1155/2012/959746 |
| spellingShingle | Charles H. Halsted Valentina Medici Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis International Journal of Hepatology |
| title | Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis |
| title_full | Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis |
| title_fullStr | Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis |
| title_full_unstemmed | Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis |
| title_short | Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis |
| title_sort | aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis |
| url | http://dx.doi.org/10.1155/2012/959746 |
| work_keys_str_mv | AT charleshhalsted aberranthepaticmethioninemetabolismandgenemethylationinthepathogenesisandtreatmentofalcoholicsteatohepatitis AT valentinamedici aberranthepaticmethioninemetabolismandgenemethylationinthepathogenesisandtreatmentofalcoholicsteatohepatitis |