Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma

Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous and immunosuppressive malignancy that frequently exhibits poor responses to immunotherapy, primarily due to immune evasion mediated by myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. Despite increasing interest...

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Bibliographic Details
Main Authors: Ziqi Guo, Qiuling Huang, Zhenzhen Cui, Cheng Yang, Liu Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
pH-responsive nanoparticles
YTHDF2
Myeloid-derived suppressor cells
m6A modification
siRNA therapy
Hepatocellular carcinoma immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03538-0
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