Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells
Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carbopla...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/6264931 |
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| _version_ | 1850227458429681664 |
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| author | Simona Ceccarelli Francesca Megiorni Diana Bellavia Cinzia Marchese Isabella Screpanti Saula Checquolo |
| author_facet | Simona Ceccarelli Francesca Megiorni Diana Bellavia Cinzia Marchese Isabella Screpanti Saula Checquolo |
| author_sort | Simona Ceccarelli |
| collection | DOAJ |
| description | Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carboplatin, contributing to chemoresistance and poor survival of OC-bearing patients. This suggests that Notch3 can represent both a biomarker and a target for therapeutic interventions in OC patients. Although it is still unclear how chemoresistance arises, different lines of evidence support a critical role of cancer stem cells (CSCs), suggesting that CSC targeting by innovative therapeutic approaches might represent a promising tool to efficiently reduce OC recurrence. To date, CSC-directed therapies in OC tumors are mainly targeted to the inhibition of CSC-related signaling pathways, including Notch. As it is increasingly evident the involvement of Notch signaling, and in particular of Notch3, in regulating stem-like cell maintenance and expansion in several tumors, here we provide an overview of the current knowledge of Notch3 role in CSC-mediated OC chemoresistance, finally exploring the potential design of innovative Notch3 inhibition-based therapies for OC treatment, aimed at eradicating tumor through the suppression of CSCs. |
| format | Article |
| id | doaj-art-2be4a876d9614aa8bfa50238a13c45fb |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2be4a876d9614aa8bfa50238a13c45fb2025-08-20T02:04:49ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/62649316264931Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem CellsSimona Ceccarelli0Francesca Megiorni1Diana Bellavia2Cinzia Marchese3Isabella Screpanti4Saula Checquolo5Department of Experimental Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Molecular Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Molecular Medicine, “Sapienza” University of Rome, Rome, ItalyDepartment of Medico-Surgical Sciences and Biotechnology, Sapienza University, Latina, ItalyNotch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carboplatin, contributing to chemoresistance and poor survival of OC-bearing patients. This suggests that Notch3 can represent both a biomarker and a target for therapeutic interventions in OC patients. Although it is still unclear how chemoresistance arises, different lines of evidence support a critical role of cancer stem cells (CSCs), suggesting that CSC targeting by innovative therapeutic approaches might represent a promising tool to efficiently reduce OC recurrence. To date, CSC-directed therapies in OC tumors are mainly targeted to the inhibition of CSC-related signaling pathways, including Notch. As it is increasingly evident the involvement of Notch signaling, and in particular of Notch3, in regulating stem-like cell maintenance and expansion in several tumors, here we provide an overview of the current knowledge of Notch3 role in CSC-mediated OC chemoresistance, finally exploring the potential design of innovative Notch3 inhibition-based therapies for OC treatment, aimed at eradicating tumor through the suppression of CSCs.http://dx.doi.org/10.1155/2019/6264931 |
| spellingShingle | Simona Ceccarelli Francesca Megiorni Diana Bellavia Cinzia Marchese Isabella Screpanti Saula Checquolo Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells Stem Cells International |
| title | Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells |
| title_full | Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells |
| title_fullStr | Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells |
| title_full_unstemmed | Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells |
| title_short | Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells |
| title_sort | notch3 targeting a novel weapon against ovarian cancer stem cells |
| url | http://dx.doi.org/10.1155/2019/6264931 |
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