Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential rol...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/968549 |
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| author | Ning Qu Mingli Xu Izuru Mizoguchi Jun-ichi Furusawa Kotaro Kaneko Kazunori Watanabe Junichiro Mizuguchi Masahiro Itoh Yutaka Kawakami Takayuki Yoshimoto |
| author_facet | Ning Qu Mingli Xu Izuru Mizoguchi Jun-ichi Furusawa Kotaro Kaneko Kazunori Watanabe Junichiro Mizuguchi Masahiro Itoh Yutaka Kawakami Takayuki Yoshimoto |
| author_sort | Ning Qu |
| collection | DOAJ |
| description | T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases. |
| format | Article |
| id | doaj-art-2be3e51c1ce049c993b3c08bb114d690 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2be3e51c1ce049c993b3c08bb114d6902025-08-20T03:55:17ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/968549968549Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory DiseasesNing Qu0Mingli Xu1Izuru Mizoguchi2Jun-ichi Furusawa3Kotaro Kaneko4Kazunori Watanabe5Junichiro Mizuguchi6Masahiro Itoh7Yutaka Kawakami8Takayuki Yoshimoto9Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDivision of Cellular Signaling, Institute for Advanced Medical Research School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, JapanDepartment of Immunology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDepartment of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanDivision of Cellular Signaling, Institute for Advanced Medical Research School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, JapanT-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.http://dx.doi.org/10.1155/2013/968549 |
| spellingShingle | Ning Qu Mingli Xu Izuru Mizoguchi Jun-ichi Furusawa Kotaro Kaneko Kazunori Watanabe Junichiro Mizuguchi Masahiro Itoh Yutaka Kawakami Takayuki Yoshimoto Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases Clinical and Developmental Immunology |
| title | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
| title_full | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
| title_fullStr | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
| title_full_unstemmed | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
| title_short | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
| title_sort | pivotal roles of t helper 17 related cytokines il 17 il 22 and il 23 in inflammatory diseases |
| url | http://dx.doi.org/10.1155/2013/968549 |
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