Genetic advancements in breast cancer treatment: a review
Abstract Breast cancer (BC) remains a leading cause of cancer-related deaths among women globally, highlighting the urgent need for more effective and targeted therapies. Traditional treatments, including surgery, chemotherapy, and radiation, face limitations such as drug resistance, metastasis, and...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01884-x |
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| author | Marzieh Shokoohi Sadaf Sedaghatshoar Homaira Arian Milad Mokarami Fatemeh Habibi Fatemeh Bamarinejad |
| author_facet | Marzieh Shokoohi Sadaf Sedaghatshoar Homaira Arian Milad Mokarami Fatemeh Habibi Fatemeh Bamarinejad |
| author_sort | Marzieh Shokoohi |
| collection | DOAJ |
| description | Abstract Breast cancer (BC) remains a leading cause of cancer-related deaths among women globally, highlighting the urgent need for more effective and targeted therapies. Traditional treatments, including surgery, chemotherapy, and radiation, face limitations such as drug resistance, metastasis, and severe side effects. Recent advancements in gene therapy, particularly CRISPR/Cas9 technology and Oncolytic Virotherapy (OVT), are transforming the BC treatment landscape. CRISPR/Cas9 enables precise gene editing to correct mutations in oncogenes like HER2 and MYC, directly addressing tumor growth and immune evasion. Simultaneously, OVT leverages genetically engineered viruses to selectively destroy cancer cells and stimulate robust antitumor immune responses. Despite their potential, gene therapies face challenges, including off-target effects, delivery issues, and ethical concerns. Innovations in delivery systems, combination strategies, and integrating gene therapy with existing treatments offer promising solutions to overcome these barriers. Personalized medicine, guided by genomic profiling, further enhances treatment precision by identifying patient-specific mutations, such as BRCA1 and BRCA2, allowing for more tailored and effective interventions. As research progresses, the constructive interaction between gene therapy, immunotherapy, and traditional approaches is paving the way for groundbreaking advancements in BC care. Continued collaboration between researchers and clinicians is essential to translate these innovations into clinical practice, ultimately improving BC patients' survival rates and quality of life. |
| format | Article |
| id | doaj-art-2be305171d204e9383502dd9b539a144 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-2be305171d204e9383502dd9b539a1442025-02-09T12:43:24ZengSpringerDiscover Oncology2730-60112025-02-0116111210.1007/s12672-025-01884-xGenetic advancements in breast cancer treatment: a reviewMarzieh Shokoohi0Sadaf Sedaghatshoar1Homaira Arian2Milad Mokarami3Fatemeh Habibi4Fatemeh Bamarinejad5Department of Life Sciences Engineering, Faculty of New Sciences & Technologies, University of TehranKent School of Social Work and Family Science, University of LouisvillePharmaceutical Biotechnology Department, Pharmacy Faculty, Anadolu UniversityStudent Research Committee, Faculty of Medicine, North Khorasan University of Medical SciencesDepartment of Speech Therapy, School of Rehabilitation, Tehran University of Medical SciencesIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesAbstract Breast cancer (BC) remains a leading cause of cancer-related deaths among women globally, highlighting the urgent need for more effective and targeted therapies. Traditional treatments, including surgery, chemotherapy, and radiation, face limitations such as drug resistance, metastasis, and severe side effects. Recent advancements in gene therapy, particularly CRISPR/Cas9 technology and Oncolytic Virotherapy (OVT), are transforming the BC treatment landscape. CRISPR/Cas9 enables precise gene editing to correct mutations in oncogenes like HER2 and MYC, directly addressing tumor growth and immune evasion. Simultaneously, OVT leverages genetically engineered viruses to selectively destroy cancer cells and stimulate robust antitumor immune responses. Despite their potential, gene therapies face challenges, including off-target effects, delivery issues, and ethical concerns. Innovations in delivery systems, combination strategies, and integrating gene therapy with existing treatments offer promising solutions to overcome these barriers. Personalized medicine, guided by genomic profiling, further enhances treatment precision by identifying patient-specific mutations, such as BRCA1 and BRCA2, allowing for more tailored and effective interventions. As research progresses, the constructive interaction between gene therapy, immunotherapy, and traditional approaches is paving the way for groundbreaking advancements in BC care. Continued collaboration between researchers and clinicians is essential to translate these innovations into clinical practice, ultimately improving BC patients' survival rates and quality of life.https://doi.org/10.1007/s12672-025-01884-xBreast cancerGene therapyCRISPR/Cas9Oncolytic virotherapyOncolytic viruses |
| spellingShingle | Marzieh Shokoohi Sadaf Sedaghatshoar Homaira Arian Milad Mokarami Fatemeh Habibi Fatemeh Bamarinejad Genetic advancements in breast cancer treatment: a review Discover Oncology Breast cancer Gene therapy CRISPR/Cas9 Oncolytic virotherapy Oncolytic viruses |
| title | Genetic advancements in breast cancer treatment: a review |
| title_full | Genetic advancements in breast cancer treatment: a review |
| title_fullStr | Genetic advancements in breast cancer treatment: a review |
| title_full_unstemmed | Genetic advancements in breast cancer treatment: a review |
| title_short | Genetic advancements in breast cancer treatment: a review |
| title_sort | genetic advancements in breast cancer treatment a review |
| topic | Breast cancer Gene therapy CRISPR/Cas9 Oncolytic virotherapy Oncolytic viruses |
| url | https://doi.org/10.1007/s12672-025-01884-x |
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