Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male
Chronic neutrophilic leukemia (CNL) is an uncommon myeloproliferative neoplasm (MPN), characterized by determined neutrophilia, bone marrow hypercellularity, and hepatosplenomegaly. The BCR-ABL1 fusion gene is not obtained. A 60-year-old male complained of a black stool. The patient also complained...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2025-01-01
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| Series: | Biomolecular and Health Science Journal |
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| Online Access: | https://journals.lww.com/10.4103/bhsj.bhsj_16_24 |
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| author | Marisa Setiawan Yetti Hernaningsih Narazah Mohd Yusoff |
| author_facet | Marisa Setiawan Yetti Hernaningsih Narazah Mohd Yusoff |
| author_sort | Marisa Setiawan |
| collection | DOAJ |
| description | Chronic neutrophilic leukemia (CNL) is an uncommon myeloproliferative neoplasm (MPN), characterized by determined neutrophilia, bone marrow hypercellularity, and hepatosplenomegaly. The BCR-ABL1 fusion gene is not obtained. A 60-year-old male complained of a black stool. The patient also complained of nausea, black vomiting, weakness, and joint pain. Anemic conjunctiva and splenomegaly were obtained. Laboratory tests showed hemoglobin 6.4 g/dL, leukocytes 46730/μL, and neutrophils 93.8%. The peripheral blood smear result was MPN: CNL. Bone marrow aspiration result matched CNL. BCR-ABL results were negative. Laboratory results 3 months later showed leukocytes 32640/μL and neutrophils 91.6%. CNL diagnosis criteria based on the 2017 World Health Organization include additional criteria if CSF3R mutation is absent: persistent neutrophilia (≥3 months), splenomegaly, and no reactive neutrophilia or plasma cell neoplasm. Proper diagnosis could prevent this disease from transforming into acute leukemia. |
| format | Article |
| id | doaj-art-2be2398f5a6748559a630409aa6d56b3 |
| institution | DOAJ |
| issn | 2620-8636 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Biomolecular and Health Science Journal |
| spelling | doaj-art-2be2398f5a6748559a630409aa6d56b32025-08-20T03:16:06ZengWolters Kluwer – Medknow PublicationsBiomolecular and Health Science Journal2620-86362025-01-0181828510.4103/bhsj.bhsj_16_24Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old MaleMarisa SetiawanYetti HernaningsihNarazah Mohd YusoffChronic neutrophilic leukemia (CNL) is an uncommon myeloproliferative neoplasm (MPN), characterized by determined neutrophilia, bone marrow hypercellularity, and hepatosplenomegaly. The BCR-ABL1 fusion gene is not obtained. A 60-year-old male complained of a black stool. The patient also complained of nausea, black vomiting, weakness, and joint pain. Anemic conjunctiva and splenomegaly were obtained. Laboratory tests showed hemoglobin 6.4 g/dL, leukocytes 46730/μL, and neutrophils 93.8%. The peripheral blood smear result was MPN: CNL. Bone marrow aspiration result matched CNL. BCR-ABL results were negative. Laboratory results 3 months later showed leukocytes 32640/μL and neutrophils 91.6%. CNL diagnosis criteria based on the 2017 World Health Organization include additional criteria if CSF3R mutation is absent: persistent neutrophilia (≥3 months), splenomegaly, and no reactive neutrophilia or plasma cell neoplasm. Proper diagnosis could prevent this disease from transforming into acute leukemia.https://journals.lww.com/10.4103/bhsj.bhsj_16_24cancerchronic neutrophilic leukemiamyeloproliferative neoplasmpersistent neutrophiliasplenomegaly |
| spellingShingle | Marisa Setiawan Yetti Hernaningsih Narazah Mohd Yusoff Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male Biomolecular and Health Science Journal cancer chronic neutrophilic leukemia myeloproliferative neoplasm persistent neutrophilia splenomegaly |
| title | Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male |
| title_full | Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male |
| title_fullStr | Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male |
| title_full_unstemmed | Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male |
| title_short | Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male |
| title_sort | chronic neutrophilic leukemia a case report of diagnosis in a 60 year old male |
| topic | cancer chronic neutrophilic leukemia myeloproliferative neoplasm persistent neutrophilia splenomegaly |
| url | https://journals.lww.com/10.4103/bhsj.bhsj_16_24 |
| work_keys_str_mv | AT marisasetiawan chronicneutrophilicleukemiaacasereportofdiagnosisina60yearoldmale AT yettihernaningsih chronicneutrophilicleukemiaacasereportofdiagnosisina60yearoldmale AT narazahmohdyusoff chronicneutrophilicleukemiaacasereportofdiagnosisina60yearoldmale |