Chronic Neutrophilic Leukemia: A Case Report of Diagnosis in a 60-year-old Male
Chronic neutrophilic leukemia (CNL) is an uncommon myeloproliferative neoplasm (MPN), characterized by determined neutrophilia, bone marrow hypercellularity, and hepatosplenomegaly. The BCR-ABL1 fusion gene is not obtained. A 60-year-old male complained of a black stool. The patient also complained...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer – Medknow Publications
2025-01-01
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| Series: | Biomolecular and Health Science Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/bhsj.bhsj_16_24 |
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| Summary: | Chronic neutrophilic leukemia (CNL) is an uncommon myeloproliferative neoplasm (MPN), characterized by determined neutrophilia, bone marrow hypercellularity, and hepatosplenomegaly. The BCR-ABL1 fusion gene is not obtained. A 60-year-old male complained of a black stool. The patient also complained of nausea, black vomiting, weakness, and joint pain. Anemic conjunctiva and splenomegaly were obtained. Laboratory tests showed hemoglobin 6.4 g/dL, leukocytes 46730/μL, and neutrophils 93.8%. The peripheral blood smear result was MPN: CNL. Bone marrow aspiration result matched CNL. BCR-ABL results were negative. Laboratory results 3 months later showed leukocytes 32640/μL and neutrophils 91.6%. CNL diagnosis criteria based on the 2017 World Health Organization include additional criteria if CSF3R mutation is absent: persistent neutrophilia (≥3 months), splenomegaly, and no reactive neutrophilia or plasma cell neoplasm. Proper diagnosis could prevent this disease from transforming into acute leukemia. |
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| ISSN: | 2620-8636 |