Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex

Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex

Abstract Our study aims to determine the effects of alamandine, the newest component of the renin-angiotensin system, on cognitive functions, neuroinflammation, and oxidative stress in the pathophysiology of depression. 35 male Sprague dawley rats, three months old, weighing between 300 and 350 g, w...

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Bibliographic Details
Main Authors: Aysu Kilic, Betul Esra Ipek, Suzin Tatonyan, Kubra Kilic, Huri Demirci, Fatmahan Atalar, Savas Ustunova, Nuran Dariyerli
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Alamandine
Depression
Neuroinflammation
Renin-angiotensin system
Spatial memory
Online Access:https://doi.org/10.1038/s41598-025-95683-7
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