Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China
Purpose The National Colorectal Cancer Cohort (NCRCC) study aims to specifically assess risk factors and biomarkers related to endpoints across the colorectal cancer continuum from the aetiology through survivorship.Participants The NCRCC study includes the Colorectal Cancer Screening Cohort (CRCSC)...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e051397.full |
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| author | Kun Chen Meilin Wang Qian Xiao Xifeng Wu Shu Zheng Zhizhong Pan Jiaqi Chen Zhaoxu Zheng Yingshuang Zhu Yeting Hu Xiangxing Kong Ye Wei Wang Ziqiang Da Wang Kefeng Ding |
| author_facet | Kun Chen Meilin Wang Qian Xiao Xifeng Wu Shu Zheng Zhizhong Pan Jiaqi Chen Zhaoxu Zheng Yingshuang Zhu Yeting Hu Xiangxing Kong Ye Wei Wang Ziqiang Da Wang Kefeng Ding |
| author_sort | Kun Chen |
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| description | Purpose The National Colorectal Cancer Cohort (NCRCC) study aims to specifically assess risk factors and biomarkers related to endpoints across the colorectal cancer continuum from the aetiology through survivorship.Participants The NCRCC study includes the Colorectal Cancer Screening Cohort (CRCSC), which recruited individuals who were at high risk of CRC between 2016 and 2020 and Colorectal Cancer Patients Cohort (CRCPC), which recruited newly diagnosed patients with CRC between 2015 and 2020. Data collection was based on questionnaires and abstraction from electronic medical record. Items included demographic and lifestyle factors, clinical information, survivorship endpoints and other information. Multiple biospecimens including blood, tissue and urine samples were collected. Participants in CRCSC were followed by a combination of periodic survey every 5 years and annual linkage with regional or national cancer and death registries for at least 10 years. In CRCPC, follow-up was conducted with both active and passive approaches at 6, 12, 18, 24, 36, 48 and 60 months after surgery.Findings to date A total of 19 377 participants and 15 551 patients with CRC were recruited in CRCSC and in CRCPC, respectively. In CRCSC, 48.0% were men, and the average age of participants at enrolment was 58.7±8.3 years. In CRCPC, 61.4% were men, and the average age was 60.3±12.3 years with 18.9% of participants under 50 years of age.Future plans Longitudinal data and biospecimens will continue to be collected. Based on the cohorts, several studies to assess risk factors and biomarkers for CRC or its survivorship will be conducted, ultimately providing research evidence from Chinese population and optimising evidence-based guidelines across the CRC continuum. |
| format | Article |
| id | doaj-art-2be1502b9d2845dda6218e9bf121ca6f |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-2be1502b9d2845dda6218e9bf121ca6f2025-08-20T02:20:32ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-051397Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in ChinaKun Chen0Meilin Wang1Qian Xiao2Xifeng Wu3Shu Zheng4Zhizhong Pan5Jiaqi Chen6Zhaoxu Zheng7Yingshuang Zhu8Yeting Hu9Xiangxing Kong10Ye Wei11Wang Ziqiang12Da Wang13Kefeng Ding141 Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China2 Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China1 Mental Health Center, Xiangya Hospital, Central South University, Changsha, Hunan, China32 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China1 Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, ChinaNeurosurgery Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Colorectal Surgery and Oncology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartments of 1Gastrointestinal Surgery and 2Pathology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaPurpose The National Colorectal Cancer Cohort (NCRCC) study aims to specifically assess risk factors and biomarkers related to endpoints across the colorectal cancer continuum from the aetiology through survivorship.Participants The NCRCC study includes the Colorectal Cancer Screening Cohort (CRCSC), which recruited individuals who were at high risk of CRC between 2016 and 2020 and Colorectal Cancer Patients Cohort (CRCPC), which recruited newly diagnosed patients with CRC between 2015 and 2020. Data collection was based on questionnaires and abstraction from electronic medical record. Items included demographic and lifestyle factors, clinical information, survivorship endpoints and other information. Multiple biospecimens including blood, tissue and urine samples were collected. Participants in CRCSC were followed by a combination of periodic survey every 5 years and annual linkage with regional or national cancer and death registries for at least 10 years. In CRCPC, follow-up was conducted with both active and passive approaches at 6, 12, 18, 24, 36, 48 and 60 months after surgery.Findings to date A total of 19 377 participants and 15 551 patients with CRC were recruited in CRCSC and in CRCPC, respectively. In CRCSC, 48.0% were men, and the average age of participants at enrolment was 58.7±8.3 years. In CRCPC, 61.4% were men, and the average age was 60.3±12.3 years with 18.9% of participants under 50 years of age.Future plans Longitudinal data and biospecimens will continue to be collected. Based on the cohorts, several studies to assess risk factors and biomarkers for CRC or its survivorship will be conducted, ultimately providing research evidence from Chinese population and optimising evidence-based guidelines across the CRC continuum.https://bmjopen.bmj.com/content/11/12/e051397.full |
| spellingShingle | Kun Chen Meilin Wang Qian Xiao Xifeng Wu Shu Zheng Zhizhong Pan Jiaqi Chen Zhaoxu Zheng Yingshuang Zhu Yeting Hu Xiangxing Kong Ye Wei Wang Ziqiang Da Wang Kefeng Ding Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China BMJ Open |
| title | Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China |
| title_full | Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China |
| title_fullStr | Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China |
| title_full_unstemmed | Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China |
| title_short | Cohort profile: The National Colorectal Cancer Cohort (NCRCC) study in China |
| title_sort | cohort profile the national colorectal cancer cohort ncrcc study in china |
| url | https://bmjopen.bmj.com/content/11/12/e051397.full |
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