MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma

MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma

Abstract Cholesterol metabolism is abnormally active in tumour cells. Metabolic enzymes related to cholesterol metabolism are upregulated in tumours, but their nonmetabolic functions remain unclear. We found that MVK (mevalonate kinase) is upregulated in lung adenocarcinoma tissues vs. normal tissue...

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Bibliographic Details
Main Authors: Changsheng Zhou, Jia Liu, Xudong Hu, Lu Lu, Juan Hou, Jian Wang, Liqun Jiang, Shuangshuang Huang, Yu Lin, Luyao Liu, Lingling Cui, Yiqian Liu, Yufeng Huang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:European Journal of Medical Research
Subjects:
Mevalonate kinase
Lung adenocarcinoma
CGAS-Sting signalling
Kras
Online Access:https://doi.org/10.1186/s40001-024-02186-8
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