Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations
Medullary thyroid carcinoma (MTC) may arise sporadically or in familial manner. We presented sporadic and familial cases with MTC in order to raise awareness on management of such patients. Three medullary thyroid carcinoma (MTC) cases were presented. Case 1 had RET634 mutation; managed with...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2016-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1140 |
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| author | Özlem Boybeyi-Türer Doğuş Vurallı İbrahim Karnak Nazlı Gönç Emel Şule Yalçın Diclehan Orhan Nurgün Kandemir Feridun Cahit Tanyel |
| author_facet | Özlem Boybeyi-Türer Doğuş Vurallı İbrahim Karnak Nazlı Gönç Emel Şule Yalçın Diclehan Orhan Nurgün Kandemir Feridun Cahit Tanyel |
| author_sort | Özlem Boybeyi-Türer |
| collection | DOAJ |
| description |
Medullary thyroid carcinoma (MTC) may arise sporadically or in familial manner. We presented sporadic and familial cases with MTC in order to raise awareness on management of such patients. Three medullary thyroid carcinoma (MTC) cases were presented. Case 1 had RET634 mutation; managed with total thyroidectomy (TT) and cervical lymph node dissection (CLND). Case 2 had RET804 mutation; managed with prophylactic TT. Case 3 had thyroid nodule; managed with TT and CLND. Case 1 had micro-carcinomatosis foci, Case 2 had normal thyroid tissue in histopathological examination and Case 3 had medullary thyroid carcinoma with tumor negative surgical borders. Case 1 was re-operated for persisting focus of disease. Follow-up of cases were uneventful. Clinicians and surgeons should be aware of critical timing for surgery and various surgical and clinical strategies in the management of MTC in children.
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| format | Article |
| id | doaj-art-2bda97c4eb2847c49f1f4a3ae9cf2e07 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-2bda97c4eb2847c49f1f4a3ae9cf2e072025-08-20T03:00:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-08-0158410.24953/turkjped.2016.04.017Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutationsÖzlem Boybeyi-Türer0Doğuş Vurallı1İbrahim Karnak2Nazlı Gönç3Emel Şule Yalçın4Diclehan Orhan5Nurgün Kandemir6Feridun Cahit Tanyel7Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Endocrinology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Endocrinology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Pediatric Pathology, Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Endocrinology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey. Medullary thyroid carcinoma (MTC) may arise sporadically or in familial manner. We presented sporadic and familial cases with MTC in order to raise awareness on management of such patients. Three medullary thyroid carcinoma (MTC) cases were presented. Case 1 had RET634 mutation; managed with total thyroidectomy (TT) and cervical lymph node dissection (CLND). Case 2 had RET804 mutation; managed with prophylactic TT. Case 3 had thyroid nodule; managed with TT and CLND. Case 1 had micro-carcinomatosis foci, Case 2 had normal thyroid tissue in histopathological examination and Case 3 had medullary thyroid carcinoma with tumor negative surgical borders. Case 1 was re-operated for persisting focus of disease. Follow-up of cases were uneventful. Clinicians and surgeons should be aware of critical timing for surgery and various surgical and clinical strategies in the management of MTC in children. https://turkjpediatr.org/article/view/1140RET proto-oncogenemedullary thyroid carcinomamultiple endocrine neoplasiasurgery |
| spellingShingle | Özlem Boybeyi-Türer Doğuş Vurallı İbrahim Karnak Nazlı Gönç Emel Şule Yalçın Diclehan Orhan Nurgün Kandemir Feridun Cahit Tanyel Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations The Turkish Journal of Pediatrics RET proto-oncogene medullary thyroid carcinoma multiple endocrine neoplasia surgery |
| title | Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations |
| title_full | Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations |
| title_fullStr | Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations |
| title_full_unstemmed | Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations |
| title_short | Surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto-oncogene mutations |
| title_sort | surgical and clinical strategies in the management of thyroid medullary carcinoma in children with and without ret proto oncogene mutations |
| topic | RET proto-oncogene medullary thyroid carcinoma multiple endocrine neoplasia surgery |
| url | https://turkjpediatr.org/article/view/1140 |
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