Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022.
<h4>Background</h4>The Japanese encephalitis virus (JEV) is transmitted by mosquitoes and circulates in Asia, the western Pacific, and other parts of the world. It is classified into five genotypes (GI-GV) based on the nucleotide sequence of the envelope (E) gene. Despite extensive surve...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-07-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0013258 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850075595530043392 |
|---|---|
| author | Bo-Ram Yun Ji-Young Kwon Byung-Eon Noh Sehoon Cho Dongmi Kwak Hee Il Lee |
| author_facet | Bo-Ram Yun Ji-Young Kwon Byung-Eon Noh Sehoon Cho Dongmi Kwak Hee Il Lee |
| author_sort | Bo-Ram Yun |
| collection | DOAJ |
| description | <h4>Background</h4>The Japanese encephalitis virus (JEV) is transmitted by mosquitoes and circulates in Asia, the western Pacific, and other parts of the world. It is classified into five genotypes (GI-GV) based on the nucleotide sequence of the envelope (E) gene. Despite extensive surveillance, shifts in genotype distribution and mosquito species remain underreported, particularly in the Republic of Korea.<h4>Methodology/principal findings</h4>We conducted a nationwide mosquito collection from 2017 to 2022, capturing 1,102,031 mosquitoes from 32 sites nationwide. The predominant species were Aedes vexans (34.2%), Culex pipiens (17.9%), Cx. tritaeniorhynchus (13.4%), Ae. albopictus (4.0%), and Cx. orientalis (0.6%). JEV was detected in 49 pools, with the majority from Cx. pipiens and Cx. tritaeniorhynchus. Genetic analyses identified genotypes I, III, and V, with genotype V becoming dominant from 2020 onwards.<h4>Conclusions/significance</h4>The emergence of genotype V as the dominant strain of the JEV, along with its detection in mosquito species other than the previously known Cx. tritaeniorhynchus, highlights the need for ongoing surveillance. These findings underscore the importance of developing vaccines effective against all JEV genotypes to mitigate public health risks. |
| format | Article |
| id | doaj-art-2bd7c414eac647c28b1b238ce82ab7d2 |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-2bd7c414eac647c28b1b238ce82ab7d22025-08-20T02:46:16ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-07-01197e001325810.1371/journal.pntd.0013258Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022.Bo-Ram YunJi-Young KwonByung-Eon NohSehoon ChoDongmi KwakHee Il Lee<h4>Background</h4>The Japanese encephalitis virus (JEV) is transmitted by mosquitoes and circulates in Asia, the western Pacific, and other parts of the world. It is classified into five genotypes (GI-GV) based on the nucleotide sequence of the envelope (E) gene. Despite extensive surveillance, shifts in genotype distribution and mosquito species remain underreported, particularly in the Republic of Korea.<h4>Methodology/principal findings</h4>We conducted a nationwide mosquito collection from 2017 to 2022, capturing 1,102,031 mosquitoes from 32 sites nationwide. The predominant species were Aedes vexans (34.2%), Culex pipiens (17.9%), Cx. tritaeniorhynchus (13.4%), Ae. albopictus (4.0%), and Cx. orientalis (0.6%). JEV was detected in 49 pools, with the majority from Cx. pipiens and Cx. tritaeniorhynchus. Genetic analyses identified genotypes I, III, and V, with genotype V becoming dominant from 2020 onwards.<h4>Conclusions/significance</h4>The emergence of genotype V as the dominant strain of the JEV, along with its detection in mosquito species other than the previously known Cx. tritaeniorhynchus, highlights the need for ongoing surveillance. These findings underscore the importance of developing vaccines effective against all JEV genotypes to mitigate public health risks.https://doi.org/10.1371/journal.pntd.0013258 |
| spellingShingle | Bo-Ram Yun Ji-Young Kwon Byung-Eon Noh Sehoon Cho Dongmi Kwak Hee Il Lee Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. PLoS Neglected Tropical Diseases |
| title | Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. |
| title_full | Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. |
| title_fullStr | Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. |
| title_full_unstemmed | Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. |
| title_short | Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022. |
| title_sort | genetic shifts of japanese encephalitis virus jev in mosquitoes in the republic of korea 2017 2022 |
| url | https://doi.org/10.1371/journal.pntd.0013258 |
| work_keys_str_mv | AT boramyun geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 AT jiyoungkwon geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 AT byungeonnoh geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 AT sehooncho geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 AT dongmikwak geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 AT heeillee geneticshiftsofjapaneseencephalitisvirusjevinmosquitoesintherepublicofkorea20172022 |