Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases
Background: Recent studies suggest neuromodulation as a potential therapeutic strategy for neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD), despite their complex pathophysiology and limited treatments' efficacy, requiring further investigation. O...
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000071 |
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| author | Mega Obukohwo Oyovwi Kehinde Henrietta Babawale Ejayeta Jeroh Benneth Ben-Azu |
| author_facet | Mega Obukohwo Oyovwi Kehinde Henrietta Babawale Ejayeta Jeroh Benneth Ben-Azu |
| author_sort | Mega Obukohwo Oyovwi |
| collection | DOAJ |
| description | Background: Recent studies suggest neuromodulation as a potential therapeutic strategy for neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD), despite their complex pathophysiology and limited treatments' efficacy, requiring further investigation. Objective: This study aims to explore the impact of neuromodulation techniques on the symptoms and progression of AD and PD, focusing on their underlying mechanisms and therapeutic benefits. Method: A comprehensive review of recent literature was conducted, encompassing published articles, results of clinical trials, animal studies, and meta-analyses regarding various neuromodulation techniques, including transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and transcranial direct current stimulation (tDCS). Data on cognitive function, motor control, and quality of life were extracted and analyzed. Results: Neuromodulation techniques demonstrated promising outcomes in both AD and PD. TMS showed significant improvement in cognitive functions in AD patients, while DBS resulted in substantial relief of motor symptoms and improved quality of life in PD patients. Additionally, mechanisms such as enhanced neuroplasticity, modulation of neurotransmitter systems, and the potential for neuroprotective effects were identified as key contributors to these benefits. Conclusion: Neuromodulation offers potential therapeutic solutions for managing symptoms and slowing neurodegenerative disorders like AD and PD, but further research is needed to understand long-term effects and optimal protocols. |
| format | Article |
| id | doaj-art-2bd0c511df1b4b09aa6364b425fc0f08 |
| institution | OA Journals |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-2bd0c511df1b4b09aa6364b425fc0f082025-08-20T02:07:19ZengElsevierBrain Disorders2666-45932025-03-011710018710.1016/j.dscb.2025.100187Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseasesMega Obukohwo Oyovwi0Kehinde Henrietta Babawale1Ejayeta Jeroh2Benneth Ben-Azu3Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, Nigeria; Department of Human Physiology, Faculty of Basic Medical Sciences, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria; Corresponding author at: Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, Nigeria.Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, NigeriaBiology Department, Federal Government Centre, Warri, Delta State, Nigeria; Department of Human Physiology, Faculty of Basic Medical Sciences, Delta State University of Science and Technology, Ozoro, Delta State, NigeriaDELSU Joint Canada-Israel Neuroscience and Biopsychiatry Laboratory, Department of Pharmacology, Delta State University, Abraka, Delta State 330106, NigeriaBackground: Recent studies suggest neuromodulation as a potential therapeutic strategy for neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD), despite their complex pathophysiology and limited treatments' efficacy, requiring further investigation. Objective: This study aims to explore the impact of neuromodulation techniques on the symptoms and progression of AD and PD, focusing on their underlying mechanisms and therapeutic benefits. Method: A comprehensive review of recent literature was conducted, encompassing published articles, results of clinical trials, animal studies, and meta-analyses regarding various neuromodulation techniques, including transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and transcranial direct current stimulation (tDCS). Data on cognitive function, motor control, and quality of life were extracted and analyzed. Results: Neuromodulation techniques demonstrated promising outcomes in both AD and PD. TMS showed significant improvement in cognitive functions in AD patients, while DBS resulted in substantial relief of motor symptoms and improved quality of life in PD patients. Additionally, mechanisms such as enhanced neuroplasticity, modulation of neurotransmitter systems, and the potential for neuroprotective effects were identified as key contributors to these benefits. Conclusion: Neuromodulation offers potential therapeutic solutions for managing symptoms and slowing neurodegenerative disorders like AD and PD, but further research is needed to understand long-term effects and optimal protocols.http://www.sciencedirect.com/science/article/pii/S2666459325000071NeuromodulationAlzheimer's diseaseParkinson's diseaseTranscranial magnetic StimulationDeep brain stimulationNeurodegenerative disorders |
| spellingShingle | Mega Obukohwo Oyovwi Kehinde Henrietta Babawale Ejayeta Jeroh Benneth Ben-Azu Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases Brain Disorders Neuromodulation Alzheimer's disease Parkinson's disease Transcranial magnetic Stimulation Deep brain stimulation Neurodegenerative disorders |
| title | Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases |
| title_full | Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases |
| title_fullStr | Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases |
| title_full_unstemmed | Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases |
| title_short | Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases |
| title_sort | exploring the role of neuromodulation in neurodegenerative disorders insights from alzheimer s and parkinson s diseases |
| topic | Neuromodulation Alzheimer's disease Parkinson's disease Transcranial magnetic Stimulation Deep brain stimulation Neurodegenerative disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000071 |
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