Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem
The aim of the study was to investigate effects of glycoprotein P-coding gene MDR1 polymorphic marker C3435T on digitalis intoxication symptoms and plasma digoxin concentration increase in patient with persistent atrial fibrillation (AF). In 103 AF patients, genotyping by gene MDR1 polymorphic marke...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2006-08-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1937 |
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| author | D. A. Sychev I. V. Ignatiev D. A. Andreev L. G. Poshukaeva P. V. Kolkhir E. E. Zhukova V. G. Kukes |
| author_facet | D. A. Sychev I. V. Ignatiev D. A. Andreev L. G. Poshukaeva P. V. Kolkhir E. E. Zhukova V. G. Kukes |
| author_sort | D. A. Sychev |
| collection | DOAJ |
| description | The aim of the study was to investigate effects of glycoprotein P-coding gene MDR1 polymorphic marker C3435T on digitalis intoxication symptoms and plasma digoxin concentration increase in patient with persistent atrial fibrillation (AF). In 103 AF patients, genotyping by gene MDR1 polymorphic marker С3435T was performed in polymerase chain reaction (PCR). Balance plasma digoxin concentration was measured by polarizing fluoro-immune assay in 29 participants. Results: Plasma digoxin concentration was higher in TTgenotype patients, comparing to CC and CT genotype individuals (l,77 ± 0,17vs 1,17 ± 0,21, p = 0,02; 1,77 ± 0,17 vs 1,37 ± 0,30, p = 0,037, respectively). Glycoside intoxication syndromes were more prevalent in TTgenotype than in CC and CT genotypes (57 % vs 13 %, p = 0,0001, OR = 6,4, CI 1, 9-21,9). Therefore, TT genotype of glycoprotein P-coding gene MDR1 polymorphic marker C3435T, was associated more frequent symptoms of glycoside intoxication and higher plasma digoxin levels. |
| format | Article |
| id | doaj-art-2bcc1a4cc56845f99006d029c2320e2d |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2006-08-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-2bcc1a4cc56845f99006d029c2320e2d2025-08-20T03:43:44Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202006-08-010464681695Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problemD. A. Sychev0I. V. Ignatiev1D. A. Andreev2L. G. Poshukaeva3P. V. Kolkhir4E. E. Zhukova5V. G. Kukes6Филиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораФилиал «Клиническая фармакология» НЦ Биомедицинских технологий РАМН; Институт клинической фармакологии НЦ ЭСМП РосздравнадзораThe aim of the study was to investigate effects of glycoprotein P-coding gene MDR1 polymorphic marker C3435T on digitalis intoxication symptoms and plasma digoxin concentration increase in patient with persistent atrial fibrillation (AF). In 103 AF patients, genotyping by gene MDR1 polymorphic marker С3435T was performed in polymerase chain reaction (PCR). Balance plasma digoxin concentration was measured by polarizing fluoro-immune assay in 29 participants. Results: Plasma digoxin concentration was higher in TTgenotype patients, comparing to CC and CT genotype individuals (l,77 ± 0,17vs 1,17 ± 0,21, p = 0,02; 1,77 ± 0,17 vs 1,37 ± 0,30, p = 0,037, respectively). Glycoside intoxication syndromes were more prevalent in TTgenotype than in CC and CT genotypes (57 % vs 13 %, p = 0,0001, OR = 6,4, CI 1, 9-21,9). Therefore, TT genotype of glycoprotein P-coding gene MDR1 polymorphic marker C3435T, was associated more frequent symptoms of glycoside intoxication and higher plasma digoxin levels.https://russjcardiol.elpub.ru/jour/article/view/1937persistent atrial fibrillationdigitalis intoxication symptomsplasma digoxin concentration increaseeffects of glycoprotein pfcoding gene mdr1 polymorphic marker с3435т |
| spellingShingle | D. A. Sychev I. V. Ignatiev D. A. Andreev L. G. Poshukaeva P. V. Kolkhir E. E. Zhukova V. G. Kukes Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem Российский кардиологический журнал persistent atrial fibrillation digitalis intoxication symptoms plasma digoxin concentration increase effects of glycoprotein pfcoding gene mdr1 polymorphic marker с3435т |
| title | Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem |
| title_full | Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem |
| title_fullStr | Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem |
| title_full_unstemmed | Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem |
| title_short | Glycoprotein P pharmacogenetic assessment role in digoxin pharmacotherapy individualization: a new approach for an old problem |
| title_sort | glycoprotein p pharmacogenetic assessment role in digoxin pharmacotherapy individualization a new approach for an old problem |
| topic | persistent atrial fibrillation digitalis intoxication symptoms plasma digoxin concentration increase effects of glycoprotein pfcoding gene mdr1 polymorphic marker с3435т |
| url | https://russjcardiol.elpub.ru/jour/article/view/1937 |
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