PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Background Immune checkpoint inhibitors and chimeric antigen receptor (CAR)-based therapies have transformed cancer treatment. Recently, combining these approaches into a strategy of PD-L1-targeted CAR has been proposed to target PD-L1high tumors. Our study provides new information on the efficacy o...

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Main Authors: Leszek Pączek, Radoslaw Zagozdzon, Karl-Johan Malmberg, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Sébastien Wälchli, Magdalena Winiarska
Format: Article
Language:English
Published: BMJ Publishing Group 2022-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/1/e002500.full
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