Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam
Talaromycosis is a life-threatening fungal disease that primarily affects immunocompromised persons in Southeast Asia. We conducted a multicenter, case–control study recruiting participants with advanced HIV disease in Vietnam; 205 case-patients with culture-confirmed talaromycosis were matched to...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-07-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/7/25-0143_article |
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| author | Lottie Brown Brian Jonat Vo Trieu Ly Nguyen Le Nhu Tung Pham Si Lam Nguyen Tat Thanh Dang Thi Ngoc Bich Vu Phuong Thao Nguyen Thi Mai Thu Ngo Thi Hoa Thuy Le |
| author_facet | Lottie Brown Brian Jonat Vo Trieu Ly Nguyen Le Nhu Tung Pham Si Lam Nguyen Tat Thanh Dang Thi Ngoc Bich Vu Phuong Thao Nguyen Thi Mai Thu Ngo Thi Hoa Thuy Le |
| author_sort | Lottie Brown |
| collection | DOAJ |
| description |
Talaromycosis is a life-threatening fungal disease that primarily affects immunocompromised persons in Southeast Asia. We conducted a multicenter, case–control study recruiting participants with advanced HIV disease in Vietnam; 205 case-patients with culture-confirmed talaromycosis were matched to 405 control-patients by age, sex, and CD4 count. Occupational exposure to tropical plants (odds ratio [OR] 1.73 [95% CI 1.10–2.73]; p = 0.017) and to farmed animals (OR 2.07 [95% CI 1.20–3.55]; p = 0.009) were independent risk factors for talaromycosis. Talaromycosis risk was higher in participants from highland regions than in persons from lowland regions (p<0.05). Participants from lowland regions who had lived or traveled to highland regions had a higher risk for talaromycosis (OR 3.15 [95% CI 1.49–6.64]; p = 0.003). This study confirms the epidemiologic correlation between talaromycosis and soil exposure and demonstrates an epidemiologic link between talaromycosis and residence in or travel to highland regions of Vietnam.
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| format | Article |
| id | doaj-art-2bc0f599405d4bc790e3437ff4205b94 |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-2bc0f599405d4bc790e3437ff4205b942025-08-20T02:21:49ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-07-013171309131810.3201/eid3107.250143Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, VietnamLottie BrownBrian JonatVo Trieu LyNguyen Le Nhu TungPham Si LamNguyen Tat ThanhDang Thi Ngoc BichVu Phuong ThaoNguyen Thi Mai ThuNgo Thi HoaThuy Le Talaromycosis is a life-threatening fungal disease that primarily affects immunocompromised persons in Southeast Asia. We conducted a multicenter, case–control study recruiting participants with advanced HIV disease in Vietnam; 205 case-patients with culture-confirmed talaromycosis were matched to 405 control-patients by age, sex, and CD4 count. Occupational exposure to tropical plants (odds ratio [OR] 1.73 [95% CI 1.10–2.73]; p = 0.017) and to farmed animals (OR 2.07 [95% CI 1.20–3.55]; p = 0.009) were independent risk factors for talaromycosis. Talaromycosis risk was higher in participants from highland regions than in persons from lowland regions (p<0.05). Participants from lowland regions who had lived or traveled to highland regions had a higher risk for talaromycosis (OR 3.15 [95% CI 1.49–6.64]; p = 0.003). This study confirms the epidemiologic correlation between talaromycosis and soil exposure and demonstrates an epidemiologic link between talaromycosis and residence in or travel to highland regions of Vietnam. https://wwwnc.cdc.gov/eid/article/31/7/25-0143_articletalaromycosisfungibamboo ratHIV/AIDS and other retrovirusespenicilliosisPenicillium marneffei |
| spellingShingle | Lottie Brown Brian Jonat Vo Trieu Ly Nguyen Le Nhu Tung Pham Si Lam Nguyen Tat Thanh Dang Thi Ngoc Bich Vu Phuong Thao Nguyen Thi Mai Thu Ngo Thi Hoa Thuy Le Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam Emerging Infectious Diseases talaromycosis fungi bamboo rat HIV/AIDS and other retroviruses penicilliosis Penicillium marneffei |
| title | Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam |
| title_full | Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam |
| title_fullStr | Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam |
| title_full_unstemmed | Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam |
| title_short | Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam |
| title_sort | multicenter case control study of behavioral environmental and geographic risk factors for talaromycosis vietnam |
| topic | talaromycosis fungi bamboo rat HIV/AIDS and other retroviruses penicilliosis Penicillium marneffei |
| url | https://wwwnc.cdc.gov/eid/article/31/7/25-0143_article |
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