Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets
The aim of this study was to evaluate the effects of lactic acid and glyceryl lactate on growth performance, antioxidant capacity, and intestinal health in piglets. This study included 240 castrated male piglets (initial body weight: 7.50 ± 0.54 kg) assigned to four groups: CON (basal diet), LA (bas...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/14/4/391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849712071469432832 |
|---|---|
| author | Shuaiju Guo Huiling Chu Bangwang Peng Junlong Niu Xiaopeng Yang Yongpeng Guo Zhixiang Wang Wei Zhang |
| author_facet | Shuaiju Guo Huiling Chu Bangwang Peng Junlong Niu Xiaopeng Yang Yongpeng Guo Zhixiang Wang Wei Zhang |
| author_sort | Shuaiju Guo |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effects of lactic acid and glyceryl lactate on growth performance, antioxidant capacity, and intestinal health in piglets. This study included 240 castrated male piglets (initial body weight: 7.50 ± 0.54 kg) assigned to four groups: CON (basal diet), LA (basal diet + 0.5% lactic acid), GL (basal diet + 0.5% glyceryl lactate), and LG (basal diet + 0.5% lactic acid + 0.5% glyceryl lactate). Each group had six replicates of 10 piglets. The trial lasted 28 days. Compared with the control group, the GL and LG groups showed enhanced growth performance and reduced diarrhea rate in piglets. The LA and LG groups showed decreased intestinal chyme pH and increased digestive enzyme activities. Moreover, the GL and LG groups displayed elevated jejunal mRNA levels of the tight junction protein <i>occludin</i> and mucin <i>MUC2</i>, enhanced expression levels of <i>Nrf2</i> signaling pathway genes, increased activities of the antioxidant enzymes GPX and CAT, and reduced MDA content. Acidifier supplementation also modulated cecal bacterial abundance and short-chain fatty acid (SCFA) content. Genera such as <i>Faecalibaculum</i>, <i>Nocardiopsis</i>, <i>Collinsella</i>, <i>CAG269</i>, <i>Allobaculum</i>, and <i>Enterococcus</i> were affected. In conclusion, glyceryl lactate and its combination with lactic acid improved piglet growth performance by enhancing intestinal barrier function, antioxidant capacity, microbial community structure, and SCFA production. |
| format | Article |
| id | doaj-art-2bbd450cb87643c3a15696b02c8be9f5 |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-2bbd450cb87643c3a15696b02c8be9f52025-08-20T03:14:24ZengMDPI AGAntioxidants2076-39212025-03-0114439110.3390/antiox14040391Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of PigletsShuaiju Guo0Huiling Chu1Bangwang Peng2Junlong Niu3Xiaopeng Yang4Yongpeng Guo5Zhixiang Wang6Wei Zhang7College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Food and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, ChinaThe aim of this study was to evaluate the effects of lactic acid and glyceryl lactate on growth performance, antioxidant capacity, and intestinal health in piglets. This study included 240 castrated male piglets (initial body weight: 7.50 ± 0.54 kg) assigned to four groups: CON (basal diet), LA (basal diet + 0.5% lactic acid), GL (basal diet + 0.5% glyceryl lactate), and LG (basal diet + 0.5% lactic acid + 0.5% glyceryl lactate). Each group had six replicates of 10 piglets. The trial lasted 28 days. Compared with the control group, the GL and LG groups showed enhanced growth performance and reduced diarrhea rate in piglets. The LA and LG groups showed decreased intestinal chyme pH and increased digestive enzyme activities. Moreover, the GL and LG groups displayed elevated jejunal mRNA levels of the tight junction protein <i>occludin</i> and mucin <i>MUC2</i>, enhanced expression levels of <i>Nrf2</i> signaling pathway genes, increased activities of the antioxidant enzymes GPX and CAT, and reduced MDA content. Acidifier supplementation also modulated cecal bacterial abundance and short-chain fatty acid (SCFA) content. Genera such as <i>Faecalibaculum</i>, <i>Nocardiopsis</i>, <i>Collinsella</i>, <i>CAG269</i>, <i>Allobaculum</i>, and <i>Enterococcus</i> were affected. In conclusion, glyceryl lactate and its combination with lactic acid improved piglet growth performance by enhancing intestinal barrier function, antioxidant capacity, microbial community structure, and SCFA production.https://www.mdpi.com/2076-3921/14/4/391lactic acidglyceryl lactategrowth performanceantioxidant capacitySCFAsintestinal health |
| spellingShingle | Shuaiju Guo Huiling Chu Bangwang Peng Junlong Niu Xiaopeng Yang Yongpeng Guo Zhixiang Wang Wei Zhang Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets Antioxidants lactic acid glyceryl lactate growth performance antioxidant capacity SCFAs intestinal health |
| title | Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets |
| title_full | Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets |
| title_fullStr | Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets |
| title_full_unstemmed | Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets |
| title_short | Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets |
| title_sort | effects of lactic acid and glyceryl lactate on growth performance antioxidant capacity and intestinal health of piglets |
| topic | lactic acid glyceryl lactate growth performance antioxidant capacity SCFAs intestinal health |
| url | https://www.mdpi.com/2076-3921/14/4/391 |
| work_keys_str_mv | AT shuaijuguo effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT huilingchu effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT bangwangpeng effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT junlongniu effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT xiaopengyang effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT yongpengguo effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT zhixiangwang effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets AT weizhang effectsoflacticacidandglyceryllactateongrowthperformanceantioxidantcapacityandintestinalhealthofpiglets |